Campbell-Stokes P L, Taylor B J
Department of Women's and Children's Health, Otago Medical School, PO Box 913, Dunedin, New Zealand.
Diabetologia. 2005 Apr;48(4):643-8. doi: 10.1007/s00125-005-1697-3. Epub 2005 Mar 10.
AIMS/HYPOTHESIS: The aim of this study was to establish the incidence of type 1 and type 2 diabetes mellitus in children aged 0-14 years.
The New Zealand Paediatric Surveillance Unit sought monthly reporting of diabetes mellitus cases from paediatricians. All resident children aged below 15 years (1996 census risk population 832,000) who met the criteria for diagnosis of diabetes mellitus from 1 January 1999 to 31 December 2000 were included. The average annual incidence of type 1 and type 2 diabetes was calculated, as were incidence rates according to age, sex, region, ethnicity and season. Case ascertainment was estimated using hospital admission data.
There were 315 valid reports of new cases of diabetes. Of these, 298 (94.6%) had type 1 diabetes, 12 (3.8%) had type 2 diabetes and five had other specified types of diabetes. The average annual incidence of type 1 diabetes was 17.9/100,000 (95% CI: 15.9-20/100,000). Children in the South Island had a 1.5-fold higher incidence than children in the North Island, which was largely accounted for by the variation in incidence with ethnicity, in that the European rate was 4.5 times higher than the Maori rate. The average annual incidence of type 2 diabetes was 0.84/100,000 (95% CI: 0.37-1.26/100,000). Estimated case ascertainment rate was 95.2%.
CONCLUSIONS/INTERPRETATION: Type 1 diabetes incidence has doubled over the past three decades. The geographical differences previously described have persisted, and are largely explained by the ethnic variation in incidence. This population includes young adolescents with type 2 diabetes. These findings are in keeping with international trends.
目的/假设:本研究旨在确定0至14岁儿童1型和2型糖尿病的发病率。
新西兰儿科监测单位要求儿科医生每月报告糖尿病病例。纳入了1999年1月1日至2000年12月31日期间所有符合糖尿病诊断标准的15岁以下常住儿童(1996年人口普查风险人群为832,000)。计算了1型和2型糖尿病的年均发病率以及按年龄、性别、地区、种族和季节划分的发病率。使用医院入院数据估计病例确诊率。
有315份新糖尿病病例的有效报告。其中,298例(94.6%)为1型糖尿病,12例(3.8%)为2型糖尿病,5例为其他特定类型糖尿病。1型糖尿病的年均发病率为17.9/10万(95%置信区间:15.9 - 20/10万)。南岛儿童的发病率比北岛儿童高1.5倍,这在很大程度上是由发病率的种族差异造成的,即欧洲裔的发病率比毛利人高4.5倍。2型糖尿病的年均发病率为0.84/10万(95%置信区间:0.37 - 1.26/10万)。估计病例确诊率为95.2%。
结论/解读:在过去三十年中,1型糖尿病发病率翻了一番。先前描述的地理差异依然存在,且很大程度上由发病率的种族差异所解释。该人群中包括患有2型糖尿病的青少年。这些发现与国际趋势一致。