Stevens Christian V, Dieltiens Nicolai, Claeys Diederica D
Research group SynBioC, Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, B-9000 Gent, Belgium.
Org Lett. 2005 Mar 17;7(6):1117-9. doi: 10.1021/ol050050e.
[reaction: see text] Perhydro-1,3-diazepine-2,4-diones are rare and can only be prepared, up to now, by special methods. A new one-step protocol was developed, comprising N-carbamoylation using an isocyanate followed by intramolecular ring expansion. This new methodology provides a straightforward access to this interesting seven-membered skeleton.
[反应：见正文] 全氢-1,3-二氮杂䓬-2,4-二酮很罕见，到目前为止，只能通过特殊方法制备。已开发出一种新的一步法方案，包括使用异氰酸酯进行N-氨甲酰化，随后进行分子内环扩展。这种新方法为获得这种有趣的七元骨架提供了直接途径。
