Banerjee Abhisek, Sergienko Eduard, Vasile Stefan, Gupta Vineet, Vuori Kristiina, Wipf Peter
Department of Chemistry and Center for Chemical Methodologies & Library Development, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Org Lett. 2009 Jan 1;11(1):65-8. doi: 10.1021/ol802247m.
An oxidative enol ether rearrangement was the key methodology in the construction of steroid-spiroketal-RGD peptides. Biological studies demonstrated potent integrin CD11b/CD18 antagonistic effects.
氧化烯醇醚重排是构建甾体-螺环缩酮-RGD肽的关键方法。生物学研究表明其具有强大的整合素CD11b/CD18拮抗作用。