Yan Bin, Liu Yuanhong
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People's Republic of China.
Org Lett. 2007 Oct 11;9(21):4323-6. doi: 10.1021/ol701886e. Epub 2007 Sep 14.
A gold(III)-catalyzed multicomponent coupling/cycloisomerization reaction of heteroaryl aldehydes, amines, and alkynes under solvent-free conditions or in water has been developed. This methodology provides rapid access to substituted aminoindolizines with high atom economy and high catalytic efficiency. Especially, the coupling of enantiomerically enriched amino acid derivatives produces the corresponding N-indolizine-incorporated amino acid derivatives without loss of enantiomeric purity.
已开发出一种在无溶剂条件下或在水中进行的金（III）催化的杂芳醛、胺和炔烃的多组分偶联/环异构化反应。该方法能够以高原子经济性和高催化效率快速合成取代的氨基中氮茚。特别地，对映体富集的氨基酸衍生物的偶联反应能够生成相应的含中氮茚的氨基酸衍生物，且对映体纯度不损失。
