Feghali-Bostwick Carol A
Division of Pulmonary, Allergy, and Critical Care Medicine, Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Department of Medicine, 628 NW MUH, 3459 Fifth Ave, Pittsburgh, PA 15213, USA.
Curr Rheumatol Rep. 2005 Apr;7(2):129-34. doi: 10.1007/s11926-005-0065-0.
The pathogenesis of systemic sclerosis (SSc; scleroderma) is still enigmatic. Genetic, familial, and twin studies suggest that SSc occurs in genetically susceptible individuals. Recent high-throughput technologies, including gene expression profiling and proteomics, have accelerated the rate of information acquired on possible mechanisms involved in SSc pathogenesis. The potential of the data obtained lies in their use for identifying new disease markers, monitoring disease activity, and developing tailored therapies. The result is an era of unprecedented advance that will benefit SSc and many other diseases.
系统性硬化症（SSc；硬皮病）的发病机制仍然是个谜。遗传学、家族性和双胞胎研究表明，SSc发生于具有遗传易感性的个体中。包括基因表达谱分析和蛋白质组学在内的近期高通量技术，加快了获取有关SSc发病机制潜在机制信息的速度。所获得数据的潜力在于可用于识别新的疾病标志物、监测疾病活动以及开发量身定制的疗法。其结果是一个前所未有的进步时代，这将造福于SSc及许多其他疾病。
