Graduate Program in Pharmacology & Toxicology, University of Connecticut, Storrs, CT 06269-3092, USA.
Cytokine Growth Factor Rev. 2012 Jun;23(3):109-18. doi: 10.1016/j.cytogfr.2012.04.002. Epub 2012 Apr 28.
A vast number of cellular processes and signaling pathways are regulated by various receptors, ranging from transmembrane to nuclear receptors. These receptor-mediated processes are modulated by a diverse set of regulatory proteins. TNFα-induced protein 3-interacting protein 1 is such a protein that inhibits both transduction by transmembrane receptors, such as TNFα-receptor, EGF-R, and TLR, and nuclear receptors' PPAR and RAR activity. These receptors play key roles in regulating inflammation and inflammatory diseases. A growing number of references have implicated TNIP1 through GWAS and expression studies in chronic inflammatory diseases such as psoriasis and rheumatoid arthritis, although TNIP1s exact role has yet been determined. In this review, we aim to integrate the current knowledge of TNIP1s functions with the diseases in which it has been associated to potentially elucidate the role this regulator has in promoting or alleviating these inflammatory diseases.
大量的细胞过程和信号通路受到各种受体的调节，这些受体从跨膜受体到核受体都有。这些受体介导的过程受到多种调节蛋白的调节。TNFα 诱导蛋白 3 相互作用蛋白 1 就是这样一种蛋白，它抑制了跨膜受体（如 TNFα 受体、EGF-R 和 TLR）和核受体的 PPAR 和 RAR 活性的转导。这些受体在调节炎症和炎症性疾病中起着关键作用。越来越多的参考文献通过 GWAS 和表达研究将 TNIP1 与慢性炎症性疾病（如银屑病和类风湿关节炎）联系起来，尽管 TNIP1 的确切作用尚未确定。在这篇综述中，我们旨在整合 TNIP1 功能的现有知识及其与疾病的关联，以潜在阐明该调节剂在促进或缓解这些炎症性疾病中的作用。
