紫外线辐射、基底细胞癌部位与组织学、宿主特征以及进一步肿瘤发生速率之间的关联。
Associations between ultraviolet radiation, basal cell carcinoma site and histology, host characteristics, and rate of development of further tumors.
作者信息
Lovatt Tracy J, Lear John T, Bastrilles Jean, Wong Christina, Griffiths Christopher E M, Samarasinghe Venura, Roebuck Jamie, Ramachandran Sudarshan, Smith Andrew G, Jones Peter W, Fryer Anthony A, Strange Richard C
机构信息
Human Genomics Research Group, Institute of Science and Technology in Medicine, Keele University School of Medicine, Hartshill Campus, University Hospital of North Staffordshire, United Kingdom.
出版信息
J Am Acad Dermatol. 2005 Mar;52(3 Pt 1):468-73. doi: 10.1016/j.jaad.2004.08.060.
BACKGROUND
Patients with basal cell carcinoma (BCC) frequently develop further tumors during follow-up.
OBJECTIVE
We sought to elucidate the relative effects of pattern of ultraviolet radiation exposure, and site and histologic type of the first tumor, on the rate of increase in BCC numbers.
METHODS
We used negative binomial regression analysis to study the association of selected variables on the rate of increase in BCC numbers in 266 Caucasian patients who first presented with a tumor on the head/neck or trunk with nodular or superficial histology.
RESULTS
Patients with an initial truncal BCC with superficial histology demonstrated significantly faster increases in BCC numbers than did patients with other site and histology combinations.
CONCLUSIONS
These data indicate that site and histology define subsets of patients with BCC.
背景
基底细胞癌（BCC）患者在随访期间经常会出现更多肿瘤。
目的
我们试图阐明紫外线辐射暴露模式、首个肿瘤的部位和组织学类型对基底细胞癌数量增加率的相对影响。
方法
我们采用负二项回归分析，研究了266例首次出现头部/颈部或躯干肿瘤且组织学类型为结节性或浅表性的白种人患者中，所选变量与基底细胞癌数量增加率之间的关联。
结果
初始肿瘤位于躯干且组织学类型为浅表性的患者，其基底细胞癌数量的增加速度明显快于其他部位和组织学类型组合的患者。
结论
这些数据表明，部位和组织学类型可界定基底细胞癌患者的亚组。
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