Vornicescu Corina, Ungureanu Loredana, Șenilă Simona Corina, Vesa Ștefan Cristian, Cosgarea Rodica, Baican Corina Iulia, Mihu Mihaela Carmen
Department of Morphological Sciences-Histology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Department of Dermatology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Exp Ther Med. 2020 Dec;20(6):187. doi: 10.3892/etm.2020.9317. Epub 2020 Oct 13.
Ultraviolet radiation (UV), mainly from sunlight, is the main risk factor of the most common human skin cancer, basal cell carcinoma (BCC). A positive effect of UV on the skin is its contribution to the synthesis of vitamin D, which is important in sustaining general health, but having high levels of vitamin D is considered a risk factor for BCC. However, vitamin D receptor has antagonistic effects to UV radiation in regulating Sonic Hedgehog pathway. This is a pilot study aimed at characterizing the sun-related behavior and vitamin D status of 52 BCC patients and 59 controls from our geographical area. Patients were included in 4 subgroups: Single, multiple, recurrent, and both multiple and recurrent BCCs. Patients, more than controls, had at least one sunburn in childhood and lentigines (P<0.001). Also, they spent daily, on average, more time in the sun than controls (P<0.001) (3.00-8.00 and 1.50-4.00 h respectively). Outdoor work was similar in both groups. Participants had lower vitamin D serum levels than expected. Due to the small number of cases, no statistically significant differences were found between the subgroups but some tendencies were noted. Patients with only one recurrent BCC had less sunburns than the ones who also developed tumors at multiple sites (P=0.2). Patients with multiple and recurrent tumors had slightly lower vitamin D levels compared with single BCC patients (P=0.1) although they used more vitamin D supplements after the BCC diagnosis (P=0.2). Having a diagnosis of BCC, made patients more compliant to the use of sunscreen cream, but even so, half of them still did not use it. In conclusion, more effort should be invested in sun-related education and public health actions should focus on vitamin D deficiencies.
紫外线辐射（UV）主要来自阳光，是人类最常见的皮肤癌——基底细胞癌（BCC）的主要风险因素。紫外线对皮肤的一个积极作用是有助于维生素D的合成，这对维持整体健康很重要，但维生素D水平过高被认为是基底细胞癌的一个风险因素。然而，维生素D受体在调节音猬因子信号通路方面对紫外线辐射具有拮抗作用。这是一项初步研究，旨在描述我们所在地区52例基底细胞癌患者和59例对照者与阳光相关的行为及维生素D状况。患者被分为4个亚组：单发、多发、复发以及既多发又复发的基底细胞癌患者。与对照组相比，患者在童年时期至少有一次晒伤和雀斑的情况更多（P<0.001）。此外，他们平均每天在阳光下的时间比对照组更长（P<0.001）（分别为3.00 - 8.00小时和1.50 - 4.00小时）。两组的户外工作情况相似。参与者的血清维生素D水平低于预期。由于病例数量较少，各亚组之间未发现统计学上的显著差异，但有一些趋势值得注意。仅患有一次复发性基底细胞癌的患者晒伤次数少于那些在多个部位也发生肿瘤的患者（P = 0.2）。患有多发和复发性肿瘤的患者与单发基底细胞癌患者相比，维生素D水平略低（P = 0.1），尽管他们在基底细胞癌诊断后使用了更多的维生素D补充剂（P = 0.2）。被诊断为基底细胞癌后，患者更愿意使用防晒霜，但即便如此，仍有一半的患者未使用。总之，应在与阳光相关的教育方面投入更多努力，公共卫生行动应关注维生素D缺乏问题。
