[I型糖尿病患者接受肾脏和胰腺双重移植的冠状动脉疾病患病率]

[Prevalence of coronary artery disease in type I diabetic candidates for double transplantation (kidney and pancreas)].

作者信息

Oliveira Dinaldo C, Gusmão Filho Glauco, Nakamoto Alysson, Souza Francival L, Sá João Roberto de, Pestana José O Medina, Lima Valter C

机构信息

Hospital São Paulo, UNIFESP, São Paulo, SP.

出版信息

Arq Bras Cardiol. 2005 Feb;84(2):108-10. Epub 2005 Mar 8.

PMID:15761631

Abstract

OBJECTIVE

To assess the prevalence of coronary artery disease (CAD) in a population of type I diabetic, nephropathic patients in a dialysis program and candidates for double transplantation (kidney and pancreas).

METHODS

From January 2000 to July 2002, 58 type I diabetic patients underwent coronary cineangiography as part of an assessment protocol for double transplantation. Coronary artery disease was defined as any irregularity in the coronary arteries and was classified according to the degree of luminal stenosis as mild (< 30%), moderate (> or = 30 to 70%), and severe (> 70%).

RESULTS

The mean age of the patients was 34 +/- 12 years, and 32 (55%) were men. No patient had a history of angina or acute myocardial infarction. The major risk factors for the disease were systemic arterial hypertension in 93% of the patients, dyslipidemia in 38%, familial history in 25%, and smoking in 20%. The mean duration of diabetes was 20.8 +/- 9 years, and the duration of dialysis was 26 +/- 9 months. Coronary angiography revealed coronary artery disease in 42 (72%) patients, which was mild in 20 (34%) patients, moderate in 9 (16%), and severe in 13 (22%).

CONCLUSION

Patients with type I diabetes in a dialysis program and candidates for double transplantation had an elevated prevalence of coronary artery disease. It is worth noting that those patients had no symptoms of the disease.

摘要

目的

评估在接受透析治疗的I型糖尿病肾病患者以及双器官移植（肾和胰腺）候选者人群中冠状动脉疾病（CAD）的患病率。

方法

从2000年1月至2002年7月，58例I型糖尿病患者接受了冠状动脉造影，作为双器官移植评估方案的一部分。冠状动脉疾病定义为冠状动脉的任何不规则情况，并根据管腔狭窄程度分为轻度（<30%）、中度（≥30%至70%）和重度（>70%）。

结果

患者的平均年龄为34±12岁，32例（55%）为男性。无患者有心绞痛或急性心肌梗死病史。该疾病的主要危险因素为93%的患者存在系统性动脉高血压、38%的患者存在血脂异常、25%的患者有家族病史以及20%的患者吸烟。糖尿病平均病程为20.8±9年，透析病程为26±9个月。冠状动脉造影显示42例（72%）患者存在冠状动脉疾病，其中20例（34%）为轻度、9例（16%）为中度、13例（22%）为重度。