Dickinson Stacy, Rogers Tyson, Kasiske Bert, Bertog Stefan, Tadros George, Malik Jamil, Wilson Robert, Panetta Carmelo
University of Minnesota, Minneapolis, Minnesota, USA.
Angiology. 2008 Feb-Mar;59(1):9-15. doi: 10.1177/0003319707304579.
The prevalence and predictors of coronary artery disease were examined in people aged 40 years and younger with insulin-dependent diabetes mellitus. Analysis was performed on those who presented between 1999 and 2003 for kidney and/or pancreas transplant at the University of Minnesota, as all patients who have diabetes mellitus are required to have perioperative cardiology evaluation. The mean age was 33.5 +/- 4.4 years for 88 subjects, all had insulin-dependent diabetes mellitus, and 33% were dialysis dependent. Severe coronary artery disease was found in 18.2% of women and in 24.2% of men. Three-vessel coronary artery disease trended less in women (9.1%) compared with men (12.1%). Multivariate predictors for severe and 3-vessel coronary artery disease included prior coronary artery disease, hypertension duration, and ST-T wave changes on electrocardiogram. Coronary artery disease is twice as high as expected in young woman. Studies on early management for atherosclerosis are warranted in this high-risk population.
对40岁及以下的胰岛素依赖型糖尿病患者的冠状动脉疾病患病率及预测因素进行了研究。对1999年至2003年间在明尼苏达大学接受肾脏和/或胰腺移植的患者进行了分析，因为所有糖尿病患者都需要进行围手术期心脏评估。88名受试者的平均年龄为33.5±4.4岁，均为胰岛素依赖型糖尿病患者，33%依赖透析。18.2%的女性和24.2%的男性患有严重冠状动脉疾病。与男性（12.1%）相比，女性三支血管冠状动脉疾病的发生率较低（9.1%）。严重和三支血管冠状动脉疾病的多变量预测因素包括既往冠状动脉疾病、高血压病程以及心电图上的ST-T波改变。年轻女性冠状动脉疾病的发生率是预期的两倍。对这一高危人群进行动脉粥样硬化早期管理的研究很有必要。
