Calvo C, Verdugo C
Departamento de Bioquímica Aplicada, Facultad de Farmacia, Universidad de Concepción, Chile.
Eur J Clin Chem Clin Biochem. 1992 Jan;30(1):3-5. doi: 10.1515/cclm.1992.30.1.3.
In diabetic patients, hyperglycaemia results in the non-enzymatic glycation of apolipoprotein A-I, the major protein of human high density lipoproteins. The effect of the non-enzymatic glycation on the association of apolipoprotein A-I with high density lipoprotein in vivo has been studied in the rat. The distribution volume obtained after injection of glycated apolipoprotein A-I was 2- to 3-fold higher in kidneys and approximately 30% lower in adrenals and ovaries than that obtained with apolipoprotein A-I. Analysis by gel chromatography of serum from donor rats shows that glycation diminishes the interaction between apolipoprotein A-I and high density lipoprotein. The findings in this study suggest that non-enzymatic glycation of apolipoprotein A-I may contribute to the development of atherosclerosis in patients with diabetes mellitus.
在糖尿病患者中，高血糖会导致载脂蛋白A-I（人类高密度脂蛋白的主要蛋白质）发生非酶糖基化。已在大鼠体内研究了非酶糖基化对载脂蛋白A-I与高密度脂蛋白结合的影响。注射糖基化载脂蛋白A-I后获得的分布容积在肾脏中比注射载脂蛋白A-I后高2至3倍，而在肾上腺和卵巢中则低约30%。对供体大鼠血清进行凝胶色谱分析表明，糖基化会减少载脂蛋白A-I与高密度脂蛋白之间的相互作用。本研究结果表明，载脂蛋白A-I的非酶糖基化可能有助于糖尿病患者动脉粥样硬化的发展。
