羽叶金合欢（含羞草科）的镇痛和抗炎活性。
Antinociceptive and anti-inflammatory activities of Acacia pennata wild (Mimosaceae).
作者信息
Dongmo A B, Nguelefack T, Lacaille-Dubois M A
机构信息
Laboratoire de Biologie des Organismes animaux, Faculté des Sciences, Université de Douala, BP 24157 Douala, Cameroun.
出版信息
J Ethnopharmacol. 2005 Apr 8;98(1-2):201-6. doi: 10.1016/j.jep.2005.01.030.
The butanolic fraction of dried leaves of Acacia pennata (Mimosaceae) was tested for analgesic and anti-inflammatory activities in animal models. It showed significant protective effects against chemical stimuli (acetic acid and formalin) in the mouse. It also produced a significant increase of the threshold of sensitivity to pressure-induced pain in the rats. The extract revealed an inhibitory effect in carrageenin-induced rat paw oedema in the late phase. The results suggested that a peripheral mechanism is involved in the analgesic, associated to anti-inflammatory effect (NSAIDs-like). Among the class of compounds characterized in this fraction, flavonoids may be mainly responsible for the pharmacological activities.
对藤金合欢（含羞草科）干燥叶片的丁醇提取物在动物模型中进行了镇痛和抗炎活性测试。它对小鼠的化学刺激（乙酸和福尔马林）显示出显著的保护作用。它还使大鼠对压力诱导疼痛的敏感性阈值显著提高。该提取物在角叉菜胶诱导的大鼠足肿胀后期显示出抑制作用。结果表明，一种外周机制参与了与抗炎作用（类非甾体抗炎药）相关的镇痛作用。在该提取物中鉴定出的化合物类别中，黄酮类化合物可能是药理活性的主要原因。
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