Section Pharmacology, Shifa College of Medicine, Islamabad, Pakistane.
Inflammopharmacology. 2010 Aug;18(4):187-96. doi: 10.1007/s10787-010-0038-4.
The current study was aimed to evaluate Acacia modesta for analgesic, anti-inflammatory, and anti-platelet activities. The analgesic and anti-inflammatory effects were assessed in rodents using acetic acid and formalin-induced nociception, hot plate and carrageenan-induced rat paw oedema tests. The intraperitoneal (i.p.) administration of the methanolic extract (50 and 100 mg/kg) produced significant inhibition (P\0.01) of the acetic acid-induced writhing in mice and suppressed formalin-induced licking response of animals in both phases of the test. In the hot plate assay the plant extract (100 mg/kg) increased pain threshold of mice. Naloxone (5 mg/kg i.p.) partially reversed the analgesic effect of the extract in formalin and hot plate tests.A. modesta (100 and 200 mg/kg i.p.) exhibited sedative effect in barbiturate-induced hypnosis test similar to that produced by diazepam (10 mg/kg i.p.). The plant extract(50-200 mg/kg i.p.) produced marked anti-inflammatory effect in carrageenan-induced rat paw oedema assay comparable to diclofenac and produced a dose-dependent(0.5-2.5 mg/mL) inhibitory effect against arachidonic acid induced platelet aggregation. These data suggest that A. modesta possesses peripheral analgesic and antiinflammatory properties, with analgesic effects partially associated with the opioid system.
本研究旨在评估金合欢属植物对镇痛、抗炎和抗血小板活性的作用。采用醋酸和甲醛诱导的疼痛、热板和角叉菜胶诱导的大鼠足肿胀试验，在啮齿动物中评估了镇痛和抗炎作用。腹腔给予金合欢属植物甲醇提取物（50 和 100 mg/kg）显著抑制了小鼠的醋酸诱导的扭体反应，并抑制了试验各阶段动物的甲醛诱导舔舐反应。在热板试验中，植物提取物（100 mg/kg）增加了小鼠的疼痛阈值。纳洛酮（5 mg/kg，腹腔注射）部分逆转了提取物在甲醛和热板试验中的镇痛作用。金合欢属植物（100 和 200 mg/kg，腹腔注射）在巴比妥酸盐诱导的催眠试验中表现出与地西泮（10 mg/kg，腹腔注射）相似的镇静作用。该植物提取物（50-200 mg/kg，腹腔注射）对角叉菜胶诱导的大鼠足肿胀试验具有显著的抗炎作用，与双氯芬酸相当，并对花生四烯酸诱导的血小板聚集产生剂量依赖性（0.5-2.5 mg/mL）抑制作用。这些数据表明，金合欢属植物具有外周镇痛和抗炎特性，其镇痛作用部分与阿片样物质系统有关。
