Yimam Mesfin, Brownell Lidia, Hodges Mandee, Jia Qi
Unigen Pharmaceuticals Inc., 2660 Willamette Drive NE, Lacey,WA 98516, USA.
J Diet Suppl. 2012 Sep;9(3):155-65. doi: 10.3109/19390211.2012.708713. Epub 2012 Aug 10.
Anti-inflammatory properties of both baicalin and catechins have been widely reported. However, the reports of analgesic effects of baicalin and catechins are limited. Three commonly used pain-related animal models were employed to evaluate the analgesic activity of UP446, a standardized bioflavonoid composition of baicalin and catechins. Carrageenan-induced paw edema, formalin test, and abdominal constriction assays were used to evaluate antinociceptive activity of 150 mg/kg or 100 mg/kg oral doses of UP446. Ibuprofen was used as a reference compound in each test. Pretreatment of carrageenan-induced hyperalgesic animals with UP446 at 150 mg/kg oral dosage reduced the hypersensitivity of pain by 39.5%. Similarly, a single dose of UP446, given orally at 100 mg/kg, exhibited 58% and 71.9% inhibition in pain sensitivity compared to vehicle-treated control in writhing and formalin tests, respectively. These findings suggest that the standardized anti-inflammatory bioflavonoid composition, UP446, could also be employed to inhibit nociception.
黄芩苷和儿茶素的抗炎特性已被广泛报道。然而，关于黄芩苷和儿茶素镇痛作用的报道却很有限。我们采用了三种常用的与疼痛相关的动物模型，来评估UP446（一种标准化的黄芩苷和儿茶素生物类黄酮组合物）的镇痛活性。角叉菜胶诱导的爪肿胀、福尔马林试验和腹部收缩试验，被用于评估口服剂量为150毫克/千克或100毫克/千克的UP446的抗伤害感受活性。在每项试验中，布洛芬被用作参考化合物。以150毫克/千克的口服剂量用UP446预处理角叉菜胶诱导的痛觉过敏动物，可使疼痛超敏反应降低39.5%。同样，在扭体试验和福尔马林试验中，与赋形剂处理的对照组相比，口服100毫克/千克的单剂量UP446分别表现出58%和71.9%的疼痛敏感性抑制。这些发现表明，标准化的抗炎生物类黄酮组合物UP446也可用于抑制伤害感受。
