Sivonová Monika, Zitnanová Ingrid, Hlincíková Lucia, Skodácek Igor, Trebatická Jana, Duracková Zdenka
Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, Comenius University, Sasinkova 2, Bratislava 81372, Slovak Republic.
Stress. 2004 Sep;7(3):183-8. doi: 10.1080/10253890400012685.
Mental stress in psychiatric disease and in daily life contributes to oxidative stress in the body. In this study we investigated a connection between possible psychological stress caused by university undergraduate examinations and oxidative stress experienced by our test subjects. Some parameters of oxidative stress (single strand breaks of DNA in lymphocytes, sensitivity to lipid oxidation and antioxidant status) were studied in medical students on the day of the examination (stress condition) and compared with the same parameters obtained from the same students during the term between two examination periods (non-stress condition). The results show that in the stress condition oxidative damage to DNA and sensitivity to lipid oxidation were significantly increased (p<0.05) when compared with the same parameters in "non-stress" conditions. A significant decrease in plasma antioxidant activity (p<0.05) in students that were under stress was observed. These results suggest that during university examinations students are under increased oxidative stress.
精神疾病及日常生活中的精神压力会导致身体产生氧化应激。在本研究中，我们调查了大学本科考试可能引发的心理压力与受试对象所经历的氧化应激之间的联系。我们对医学生在考试当天（应激状态）的一些氧化应激参数（淋巴细胞中DNA的单链断裂、脂质氧化敏感性和抗氧化状态）进行了研究，并与同一批学生在两个考试时间段之间的学期内（非应激状态）获得的相同参数进行了比较。结果显示，与“非应激”状态下的相同参数相比，在应激状态下DNA的氧化损伤和脂质氧化敏感性显著增加（p<0.05）。我们观察到处于应激状态的学生血浆抗氧化活性显著降低（p<0.05）。这些结果表明，在大学考试期间，学生承受着更大的氧化应激。
