Danciu Adrian Marius, Ghitea Timea Claudia, Bungau Alexa Florina, Vesa Cosmin Mihai
Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania.
Faculty of Medicine and Pharmacy, Pharmacy Department, University of Oradea, 410068 Oradea, Romania.
J Nutr Metab. 2023 Sep 25;2023:6632197. doi: 10.1155/2023/6632197. eCollection 2023.
Oxidative stress (OS) is associated with metabolic syndrome (MS) and represents a complex disease association that has become a major challenge in the field of public health. The aim of this study was to investigate the effectiveness of introducing selenium in the management of OS, while considering a balanced diet based on a healthy lifestyle and dietary therapy. A total of 206 individuals participated voluntarily in the study, divided into three groups: the control group with 35 individuals (17.0%) designated as control lot (LC), the group undergoing diet therapy with 119 individuals (57.8%) designated as diet therapy lot (LD), and the group undergoing diet therapy supplemented with selenium consisting of 52 individuals (25.2%) designated as diet therapy with selenium lot (LD + Se). The study assessed various clinical parameters (such as body mass index (BMI), body weight status, fat mass, visceral fat, and sarcopenic index), paraclinical parameters (including HOMA index, cholesterol, triglycerides, C-reactive protein, and glycosylated haemoglobin (HGS)), as well as OS parameters (measured using the FORD test, FORT test, and MIXED test). The LD + Se group demonstrated the most favourable results in terms of BMI reduction, decreased fat and visceral mass, reduced levels of C-reactive protein, and improved glycosylated haemoglobin levels. By implementing a balanced diet therapy and supplementing the diet with selenium, it was possible to achieve a reduction in adipose tissue and glycosylated haemoglobin levels, ultimately contributing to the reduction of OS in the body.
氧化应激（OS）与代谢综合征（MS）相关，代表了一种复杂的疾病关联，已成为公共卫生领域的一项重大挑战。本研究的目的是在考虑基于健康生活方式和饮食疗法的均衡饮食的同时，探讨补充硒对氧化应激管理的有效性。共有206人自愿参与本研究，分为三组：对照组35人（17.0%），指定为对照批次（LC）；接受饮食疗法的组119人（57.8%），指定为饮食疗法批次（LD）；接受补充硒的饮食疗法的组52人（25.2%），指定为含硒饮食疗法批次（LD + Se）。该研究评估了各种临床参数（如体重指数（BMI）、体重状况、脂肪量、内脏脂肪和肌肉减少指数）、副临床参数（包括HOMA指数、胆固醇、甘油三酯、C反应蛋白和糖化血红蛋白（HGS））以及氧化应激参数（使用FORD试验、FORT试验和混合试验测量）。LD + Se组在降低BMI、减少脂肪和内脏质量、降低C反应蛋白水平以及改善糖化血红蛋白水平方面显示出最有利的结果。通过实施均衡饮食疗法并在饮食中补充硒，可以减少脂肪组织和糖化血红蛋白水平，最终有助于降低体内的氧化应激。
