Krebs I P, Krebs W, Merriam J C, Gouras P, Jones I S
Department of Cell Biology and Anatomical Sciences, City University New York, New York.
Histol Histopathol. 1992 Jan;7(1):101-10.
A 4 1/2 year old female was treated for embryonal rhabdomyosarcoma of the left orbit in 1975 with radiation (59.5 Gy in 5 weeks), followed by chemotherapy. An electroretinogram (ERG) in March, 1988 revealed cone responses 3% of normal and no rod responses in the left eye, and normal responses in the right eye. The eye was enucleated in April 1988. In the fovea no choroidocapillaris was seen at the intact Bruch's membrane, and the pigment epithelium was preserved only in small patches. No photoreceptor cells were seen in the areas devoid of pigment epithelial cells. The parafoveal and peripheral (30 degrees eccentricity) retina was better preserved. The thickness of the layer of rods and cones and of Henle's fiber layer was reduced. Very few outer segments were present. Macrophages had invaded the retinal tissue in moderate numbers. The retinal vessels were ensheathed by several layers of collagen fibrils. The spatial densities of pigment epithelial, cone, rod, and bipolar cells had been reduced. The optic nerve contained a total number of 1,022,000 nerve fibers.
一名4岁半的女性于1975年接受了左侧眼眶胚胎性横纹肌肉瘤的治疗，先进行了5周共59.5 Gy的放疗，随后进行化疗。1988年3月的视网膜电图（ERG）显示，左眼视锥细胞反应为正常的3%，无视杆细胞反应，右眼反应正常。1988年4月该眼被摘除。在黄斑中心凹，完整的布鲁赫膜处未见脉络膜毛细血管，色素上皮仅小片状保存。在无色素上皮细胞的区域未见光感受器细胞。黄斑旁和周边（偏心度30度）视网膜保存较好。视杆和视锥细胞层以及亨利纤维层厚度变薄。外节很少。巨噬细胞中等数量侵入视网膜组织。视网膜血管被几层胶原纤维包裹。色素上皮细胞、视锥细胞、视杆细胞和双极细胞的空间密度降低。视神经共有1022000条神经纤维。
