马达分子prestin在电场中能呈现多少种状态？
How many states can the motor molecule, prestin, assume in an electric field?
作者信息
Scherer Marc P, Gummer Anthony W
机构信息
Section of Physiological Acoustics and Communication, Department of Otolaryngology, University of Tübingen, Tübingen 72076, Germany.
出版信息
Biophys J. 2005 May;88(5):L27-9. doi: 10.1529/biophysj.105.059782. Epub 2005 Mar 11.
Abstract
By using an analogy between the magnetization of a paramagnetic material in an external magnetic field and the electric polarization of the lateral wall of outer hair cells in response to the transmembrane potential, we show that, based on experimental data on the charge transfer across the membrane, it is impossible to make a statement about the number of possible conformational states of the motor molecule, prestin. Although the choice of model affects the values of derived parameters, such as total charge and motor charge, this is frequently overlooked in the literature.
摘要
通过类比顺磁性材料在外加磁场中的磁化与外毛细胞侧壁响应跨膜电位的电极化，我们表明，基于跨膜电荷转移的实验数据，无法对马达分子（prestin）可能的构象状态数量做出说明。尽管模型的选择会影响诸如总电荷和马达电荷等派生参数的值，但这一点在文献中经常被忽视。
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