马达分子prestin在电场中能呈现多少种状态？
How many states can the motor molecule, prestin, assume in an electric field?
作者信息
Scherer Marc P, Gummer Anthony W
机构信息
Section of Physiological Acoustics and Communication, Department of Otolaryngology, University of Tübingen, Tübingen 72076, Germany.
出版信息
Biophys J. 2005 May;88(5):L27-9. doi: 10.1529/biophysj.105.059782. Epub 2005 Mar 11.
Abstract
By using an analogy between the magnetization of a paramagnetic material in an external magnetic field and the electric polarization of the lateral wall of outer hair cells in response to the transmembrane potential, we show that, based on experimental data on the charge transfer across the membrane, it is impossible to make a statement about the number of possible conformational states of the motor molecule, prestin. Although the choice of model affects the values of derived parameters, such as total charge and motor charge, this is frequently overlooked in the literature.
摘要
通过类比顺磁性材料在外加磁场中的磁化与外毛细胞侧壁响应跨膜电位的电极化，我们表明，基于跨膜电荷转移的实验数据，无法对马达分子（prestin）可能的构象状态数量做出说明。尽管模型的选择会影响诸如总电荷和马达电荷等派生参数的值，但这一点在文献中经常被忽视。
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How many states can the motor molecule, prestin, assume in an electric field?马达分子prestin在电场中能呈现多少种状态？
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本文引用的文献
1
Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier.Prestin是外毛细胞电运动和耳蜗放大器所必需的。
Nature. 2002 Sep 19;419(6904):300-4. doi: 10.1038/nature01059. Epub 2002 Aug 28.
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Voltage-dependent changes in specific membrane capacitance caused by prestin, the outer hair cell lateral membrane motor.由外毛细胞侧膜马达蛋白（prestin）引起的特定膜电容的电压依赖性变化。
Pflugers Arch. 2002 May;444(1-2):99-106. doi: 10.1007/s00424-002-0804-2. Epub 2002 Feb 20.
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A two-state piezoelectric model for outer hair cell motility.外毛细胞运动的双态压电模型。
Biophys J. 2001 Nov;81(5):2495-506. doi: 10.1016/S0006-3495(01)75895-X.
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Intracellular anions as the voltage sensor of prestin, the outer hair cell motor protein.细胞内阴离子作为外毛细胞运动蛋白——预应力蛋白的电压传感器。
Science. 2001 Jun 22;292(5525):2340-3. doi: 10.1126/science.1060939.
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A membrane bending model of outer hair cell electromotility.外毛细胞电运动的膜弯曲模型。
Biophys J. 2000 Jun;78(6):2844-62. doi: 10.1016/S0006-3495(00)76827-5.
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Prestin is the motor protein of cochlear outer hair cells.Prestin是耳蜗外毛细胞的运动蛋白。
Nature. 2000 May 11;405(6783):149-55. doi: 10.1038/35012009.
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Limiting dynamics of high-frequency electromechanical transduction of outer hair cells.外毛细胞高频机电转导的限制动力学
Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4420-5. doi: 10.1073/pnas.96.8.4420.
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Current noise spectrum and capacitance due to the membrane motor of the outer hair cell: theory.外毛细胞膜马达引起的电流噪声谱和电容：理论
Biophys J. 1997 Dec;73(6):2965-71. doi: 10.1016/S0006-3495(97)78325-5.
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The outer hair cell motor in membrane patches.膜片中的外毛细胞马达。
Pflugers Arch. 1997 Jul;434(3):267-71. doi: 10.1007/s004240050395.
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Theory of electrically driven shape changes of cochlear outer hair cells.耳蜗外毛细胞电驱动形状变化理论
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