Yasuda Hiroyasu, Yamaya Mutsuo, Nakayama Katsutoshi, Ebihara Satoru, Sasaki Takahiko, Okinaga Shoji, Inoue Daisuke, Asada Masanori, Nemoto Miyako, Sasaki Hidetada
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.
Am J Respir Crit Care Med. 2005 Jun 1;171(11):1246-51. doi: 10.1164/rccm.200407-914OC. Epub 2005 Mar 11.
Exhaled carbon monoxide (CO) and arterial blood carboxyhemoglobin concentrations (Hb-CO) increase in inflammatory pulmonary diseases.
To study whether arterial Hb-CO is useful to monitor disease activity in patients with chronic obstructive pulmonary disease (COPD) who had stopped smoking.
We measured arterial Hb-CO, arteriovenous Hb-CO differences, and FEV1 in 58 patients with COPD and 61 ex-smoking control subjects.
Arterial Hb-CO concentrations in patients at stable conditions were higher than those in control subjects (p < 0.0001). Furthermore, the Hb-CO concentrations in patients at the exacerbations (p < 0.0001) were higher than those at the stable conditions. Arterial Hb-CO concentrations in patients at stage III were higher than those in patients at stage II, and the Hb-CO concentrations in patients at stage IV were higher than those in patients at stage III at the stable conditions and exacerbations. Arterial Hb-CO correlated with exhaled CO in patients with COPD at stage II and stage III at the exacerbations. Arterial Hb-CO inversely correlated with the arterial blood partial oxygen pressure and FEV1. Arteriovenous Hb-CO differences in patients at the exacerbations did not differ from those in patients at stable conditions and from those in control subjects. Moreover, arterial Hb-CO correlated with serum C-reactive protein values and serum lipid peroxide concentrations.
These findings suggest that increased arterial Hb-CO may relate to severity in patients with COPD because of lung and systemic inflammation and production of reactive oxygen species.
炎症性肺部疾病患者呼出的一氧化碳（CO）和动脉血碳氧血红蛋白浓度（Hb-CO）会升高。
研究动脉血Hb-CO对已戒烟的慢性阻塞性肺疾病（COPD）患者疾病活动的监测是否有用。
我们测量了58例COPD患者和61例已戒烟对照者的动脉血Hb-CO、动静脉Hb-CO差值和第一秒用力呼气容积（FEV1）。
稳定期患者的动脉血Hb-CO浓度高于对照者（p<0.0001）。此外，急性加重期患者的Hb-CO浓度高于稳定期患者（p<0.0001）。在稳定期和急性加重期，III期患者的动脉血Hb-CO浓度高于II期患者，IV期患者的Hb-CO浓度高于III期患者。在急性加重期，II期和III期COPD患者的动脉血Hb-CO与呼出的CO相关。动脉血Hb-CO与动脉血氧分压和FEV1呈负相关。急性加重期患者的动静脉Hb-CO差值与稳定期患者及对照者无差异。此外，动脉血Hb-CO与血清C反应蛋白值和血清脂质过氧化物浓度相关。
这些发现表明，由于肺部和全身炎症以及活性氧的产生，动脉血Hb-CO升高可能与COPD患者的病情严重程度有关。
