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[药物和电刺激对大鼠脑单胺能系统的影响所引起的初级视觉皮层反应恢复周期]

[Primary visual cortex response recovery cycles caused by pharmacologic and electrical effects on the monoaminergic systems of the rat brain].

作者信息

Vorob'ev V V, Nesterova I V

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1979 May-Jun;29(3):598-604.

PMID:157649
Abstract

The recovery cycles (RC) of primary responses in the visual cortex were studied in alert rats following the electrical stimulation of raphe nuclei and locus coeruleus as well as following pharmacological and complex (electrical and pharmacological) actions on serotonin- and noradrenergic brain systems. It was found that both electrical and pharmacological actions on the above monoaminergic systems reduce the duration and depth of relative non-reactivity phase of RC. Complex (electrical and pharmacological) action leads to heterodirectional changes in RC. The character of these changes reflects the reciprocity existing in functional interrelations between serotonin- and noradrenergic brain systems. The probable connection of the found effects with memory mechanisms is discussed.

摘要

在清醒大鼠中,研究了中缝核和蓝斑电刺激后以及对血清素能和去甲肾上腺素能脑系统进行药理学和复合(电和药理学)作用后,视觉皮层初级反应的恢复周期(RC)。结果发现,对上述单胺能系统的电刺激和药理学作用均会缩短RC相对无反应期的持续时间和深度。复合(电和药理学)作用会导致RC出现异向变化。这些变化的特征反映了血清素能和去甲肾上腺素能脑系统之间功能相互关系中存在的相互作用。讨论了所发现的效应与记忆机制之间可能的联系。

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Zh Vyssh Nerv Deiat Im I P Pavlova. 1979 May-Jun;29(3):598-604.
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Recovery cycles of visual cortical primary responses during pharmacological and electrical intervention on monoaminergic systems of the rat brain.
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