Vorob'ev V V, Gal'chenko A A, Deriugina O N
Zh Vyssh Nerv Deiat Im I P Pavlova. 1990 Jan-Feb;40(1):119-24.
In experiments on 8 rabbits and 12 rats changes in electrograms of the visual cortex of alert animals were studied under photic stimulation in conditions of pharmacological action on monoamine (MA) brain systems. After injection of MA precursors (5-oxitriptophane and d, 1-dioxiphenylalanine) following phenomena were observed: a) decrease of the amplitude of the averaged evoked potentials to rhythmic photic stimuli (1-20 imp. sec.-1); b) an enhancement of fast (15-25 Hz) oscillations in the cortical spontaneous electrical activity and weakening and modification of the effects of the blockader of synthesis of MA-alpha-methyl-dioxiphenylalanine. Under light stimulation potentiation of MA precursors effects was observed in the frequency spectra of electrocorticograms. In the same conditions the specificity of action of cathecholamines precursor was revealed in the form of an increase of power of rhythms of 5-7 Hz and it; decrease in 2-3 Hz. Possible mechanisms of the revealed phenomena are discussed.
在对8只兔子和12只大鼠进行的实验中，研究了在对单胺（MA）脑系统产生药理作用的条件下，光刺激时警觉动物视觉皮层电图的变化。注射MA前体（5-羟色氨酸和d，1-二羟基苯丙氨酸）后观察到以下现象：a）对节律性光刺激（1-20次/秒）的平均诱发电位幅度降低；b）皮层自发电活动中快速（15-25赫兹）振荡增强，MA-α-甲基-二羟基苯丙氨酸合成阻断剂的作用减弱并改变。在光刺激下，在皮层电图的频谱中观察到MA前体作用的增强。在相同条件下，儿茶酚胺前体的作用特异性表现为5-7赫兹节律功率增加而2-3赫兹节律功率降低。文中讨论了所揭示现象的可能机制。
