从失败中学习：后基因组时代的充血性心力衰竭
Learning from failure: congestive heart failure in the postgenomic age.
作者信息
Benjamin Ivor J, Schneider Michael D
机构信息
Division of Cardiology, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA.
出版信息
J Clin Invest. 2005 Mar;115(3):495-9. doi: 10.1172/JCI24477.
Abstract
The prognosis of heart failure is worse than that of most cancers, but new therapeutic interventions using stem and other cell-based therapies are succeeding in the fight against it, and old drugs, with new twists, are making a comeback. Genetically engineered animal models are driving insights into the molecular mechanisms that cause hearts to fail, accelerating drug discoveries, and inspiring cell-based therapeutic interventions for both acquired and inheritable cardiac diseases.
摘要
心力衰竭的预后比大多数癌症更差，但使用干细胞和其他基于细胞的疗法的新型治疗干预措施正在成功对抗心力衰竭，而且一些有新用途的老药物也正在卷土重来。基因工程动物模型正在推动人们深入了解导致心脏衰竭的分子机制，加速药物研发，并激发针对后天性和遗传性心脏病的基于细胞的治疗干预措施。
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