Giordano Frank J
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
J Clin Invest. 2005 Mar;115(3):500-8. doi: 10.1172/JCI24408.
A constant supply of oxygen is indispensable for cardiac viability and function. However, the role of oxygen and oxygen-associated processes in the heart is complex, and they and can be either beneficial or contribute to cardiac dysfunction and death. As oxygen is a major determinant of cardiac gene expression, and a critical participant in the formation of ROS and numerous other cellular processes, consideration of its role in the heart is essential in understanding the pathogenesis of cardiac dysfunction.
持续的氧气供应对于心脏的存活和功能是不可或缺的。然而，氧气及与氧气相关的过程在心脏中的作用是复杂的，它们既可能有益，也可能导致心脏功能障碍和死亡。由于氧气是心脏基因表达的主要决定因素，也是活性氧形成及许多其他细胞过程的关键参与者，因此，考虑其在心脏中的作用对于理解心脏功能障碍的发病机制至关重要。
