Kaijser Magnus, Akre Olof, Cnattingius Sven, Ekbom Anders
Clinical Epidemiology Unit, Department of Medicine at Karolinska Hospital, Stockholm, Sweden.
Gastroenterology. 2005 Mar;128(3):607-9. doi: 10.1053/j.gastro.2004.11.049.
BACKGROUND & AIMS: Gastroesophageal reflux is common among preterm infants and those who are small for gestational age, and it is a strong risk factor for adenocarcinoma of the esophagus.
In a cohort of 3364 individuals born preterm and/or small for gestational age between 1925 and 1949, we assessed the long-term risk for esophageal cancer.
The standardized incidence rate ratio for esophageal adenocarcinoma was increased more than 7-fold in the cohort (standardized incidence rate ratio, 7.27; 95% confidence interval, 1.98-18.62), and a birth weight <2000 g was associated with a more than 11-fold increase in risk (standardized incidence rate ratio, 11.5; 95% confidence interval, 1.39-41.5).
The associations may be spurious, but if not, they may be explained by increased gastroesophageal reflux during infancy among infants born preterm and/or small for gestational age.
胃食管反流在早产儿和小于胎龄儿中很常见，并且是食管腺癌的一个重要危险因素。
在一组1925年至1949年间出生的早产和/或小于胎龄的3364名个体中，我们评估了食管癌的长期风险。
该队列中食管腺癌的标准化发病率比增加了7倍多（标准化发病率比，7.27；95%置信区间，1.98 - 18.62），出生体重<2000 g与风险增加11倍以上相关（标准化发病率比，11.5；95%置信区间，1.39 - 41.5）。
这些关联可能是虚假的，但如果不是，则可能是由于早产和/或小于胎龄儿在婴儿期胃食管反流增加所致。
