Lee Linda S, Saltzman John R, Bounds Brenna C, Poneros John M, Brugge William R, Thompson Christopher C
Gastroenterology Division, Brigham and Women's Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA.
Clin Gastroenterol Hepatol. 2005 Mar;3(3):231-6. doi: 10.1016/s1542-3565(04)00618-4.
Endoscopic ultrasound-guided fine-needle aspiration (EUS FNA) of pancreatic cysts is considered safe, however, data are conflicting regarding complication rates. The aim of this study was to determine the complication rate of EUS-guided pancreatic cyst aspiration and predictors of these complications.
Results of pancreatic cyst EUS FNA at 2 academic institutions from March 1996 to October 2003 were reviewed. A total of 603 patients with 651 pancreatic cysts were evaluated. Complications were identified from clinic, emergency department, and discharge notes, and laboratory and radiologic data. Data collected were as follows: cyst size, location, septations, diagnosis, number of passes, needle size, status as inpatient or outpatient, performance of same-day endoscopic retrograde cholangiopancreatography (ERCP), and use of prophylactic antibiotics.
Complications were identified in 13 patients (2.2%, 13 of 603): 6 patients had pancreatitis, 4 patients had abdominal pain, 1 patient had a retroperitoneal bleed, 1 patient had an infection, and 1 patient had bradycardia. Twelve patients required hospitalization, with an average length of stay of 3.8 +/- 1.1 days. Type of cyst, size, presence of septations or mass, and same-day ERCP were not predictors of complications.
EUS-guided pancreatic cyst aspiration carries a low complication rate similar to that reported for solid pancreatic lesions. No patient or cyst characteristics appear to be predictive of adverse events.
内镜超声引导下胰腺囊肿细针穿刺抽吸术（EUS-FNA）被认为是安全的，然而，关于并发症发生率的数据存在冲突。本研究的目的是确定EUS引导下胰腺囊肿抽吸术的并发症发生率以及这些并发症的预测因素。
回顾了1996年3月至2003年10月在2家学术机构进行的胰腺囊肿EUS-FNA的结果。共评估了603例患者的651个胰腺囊肿。通过临床、急诊科和出院记录以及实验室和放射学数据来确定并发症。收集的数据如下：囊肿大小、位置、分隔、诊断、穿刺次数、针的大小、住院或门诊状态、同日内镜逆行胰胆管造影（ERCP）的实施情况以及预防性抗生素的使用情况。
13例患者（2.2%，603例中的13例）出现并发症：6例患者发生胰腺炎，4例患者出现腹痛，1例患者发生腹膜后出血，1例患者发生感染，1例患者出现心动过缓。12例患者需要住院治疗，平均住院时间为3.8±1.1天。囊肿类型、大小、是否存在分隔或肿块以及同日ERCP均不是并发症的预测因素。
EUS引导下胰腺囊肿抽吸术的并发症发生率较低，与实性胰腺病变报道的发生率相似。没有患者或囊肿特征似乎可预测不良事件。
