使用激活刚度的仪器测量方法量化帕金森病僵硬中药物诱导的变化。
Quantifying drug-induced changes in parkinsonian rigidity using an instrumental measure of activated stiffness.
作者信息
Caligiuri M P, Galasko D R
机构信息
Department of Psychiatry, University of California, San Diego.
出版信息
Clin Neuropharmacol. 1992 Feb;15(1):1-12. doi: 10.1097/00002826-199202000-00001.
Abstract
We review the literature on quantifying parkinsonian rigidity and present data from 124 subjects to demonstrate the clinical utility of activated stiffness to model rigidity. This method eliminates many of the confounding variables associated with the subjective assessment of rigidity. This 5-min computer-assisted procedure was highly reliable and sensitive to pharmacologic influences that produce and reduce parkinsonian rigidity.
摘要
我们回顾了关于量化帕金森病僵硬程度的文献，并展示了来自124名受试者的数据，以证明激活僵硬度对模拟僵硬的临床实用性。该方法消除了许多与僵硬程度主观评估相关的混杂变量。这个5分钟的计算机辅助程序高度可靠，并且对产生和减轻帕金森病僵硬的药物影响敏感。
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