Valevski A, Gil-Ad I, Modai I, Apter A, Tyano S, Laron Z, Weizman A
Geha Psychiatric Hospital, Beilinson Medical Center, Petah Tiqva, Israel.
Clin Neuropharmacol. 1992 Feb;15(1):27-33. doi: 10.1097/00002826-199202000-00004.
The effect of a single dose (10 mg P.O.) of trihexyphenidyl (THP) on plasma cortisol, growth hormone (GH), and immunoreactive beta-endorphin (ir-beta-EP) was studied in seven major depressed patients and seven controls. GH secretion was suppressed (34-41%) by THP in both groups. THP did not affect cortisol secretion in depressed patients and controls. An increase (18%; p less than 0.05) in plasma ir-beta-EP levels was detected in the healthy subjects only. The results of this study do not support the hypothesized altered responsiveness to anticholinergic provocation in major depression. The inhibitory activity of THP on GH secretion indicates the involvement of the cholinergic system in the regulation of GH release in humans.
研究了单剂量（口服10毫克）的苯海索（THP）对7名重度抑郁症患者和7名对照者血浆皮质醇、生长激素（GH）及免疫反应性β-内啡肽（ir-β-EP）的影响。两组中THP均抑制了GH分泌（34%-41%）。THP对抑郁症患者和对照者的皮质醇分泌均无影响。仅在健康受试者中检测到血浆ir-β-EP水平升高（18%；p<0.05）。本研究结果不支持重度抑郁症患者对抗胆碱能激发反应改变的假说。THP对GH分泌的抑制活性表明胆碱能系统参与了人类GH释放的调节。
