Strathdee Steffanie A, Latka M, Campbell J, O'Driscoll P T, Golub E T, Kapadia F, Pollini R A, Garfein R S, Thomas D L, Hagan H
Department of Family and Preventive Medicine, Division of International Health and Cross-Cultural Medicine, University of California, San Diego, California 92093, USA.
Clin Infect Dis. 2005 Apr 15;40 Suppl 5(Suppl 5):S304-12. doi: 10.1086/427445.
We sought to identify factors associated with interest in receiving therapy for hepatitis C virus (HCV) infection among HCV-infected injection drug users (IDUs) in 3 United States cities.
IDUs aged 18-35 years who were HCV-infected and seronegative for human immunodeficiency virus underwent surveys on behaviors, experience, and interest in treatment for HCV infection and readiness to quit drug use.
Among treatment-naive IDUs (n=216), 81.5% were interested in treatment for HCV infection, but only 27.3% had seen a health-care provider since receiving a diagnosis of HCV infection. Interest in treatment for HCV infection was greater among IDUs with a high perceived threat of progressive liver disease, those with a usual source of care, those without evidence of alcohol dependence, and those with higher readiness scores for quitting drug use. Interest in treatment for HCV infection was 7-fold higher among IDUs who were told by their health-care provider that they were at risk for cirrhosis or liver cancer.
Improving provider-patient communication and integrating treatments for substance abuse and HCV may increase the proportion of IDUs who initiate treatment for HCV infection.
我们试图确定美国3个城市中感染丙型肝炎病毒（HCV）的注射吸毒者（IDU）对接受HCV感染治疗感兴趣的相关因素。
对年龄在18至35岁、感染HCV且人类免疫缺陷病毒血清学阴性的IDU进行了关于行为、经历、对HCV感染治疗的兴趣以及戒毒意愿的调查。
在未经治疗的IDU（n = 216）中，81.5%对HCV感染治疗感兴趣，但自诊断为HCV感染以来，只有27.3%看过医疗服务提供者。对HCV感染治疗兴趣较高的IDU包括：认为自身患进展性肝病风险高的、有固定医疗服务来源的、无酒精依赖证据的以及戒毒意愿得分较高的。被医疗服务提供者告知有肝硬化或肝癌风险的IDU对HCV感染治疗的兴趣高出7倍。
改善医患沟通并整合药物滥用和HCV治疗可能会增加开始接受HCV感染治疗的IDU比例。
