Doab Anna, Treloar Carla, Dore Gregory J
National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia.
Clin Infect Dis. 2005 Apr 15;40 Suppl 5:S313-20. doi: 10.1086/427446.
Despite recent improvements in outcomes of treatment for infection with hepatitis C virus (HCV), very few current injection drug users (IDUs) have access to treatment programs. We examined the natural history of and treatment knowledge about HCV infection and barriers and willingness to seek treatment for HCV infection. A convenience sample of current IDUs (n=100) with self-reported HCV-positive status drawn from a primary health facility and methadone clinic in inner Sydney completed an interviewer-administered questionnaire. Participants had a reasonable knowledge of the natural history of HCV infection but poorer knowledge of treatment for HCV infection. Most believed that being a current IDU was an exclusion criterion for treatment. Despite this, 70%-80% of IDUs reported that they would consider treatment under current scenarios in Australia: requirement for liver biopsy, subcutaneous injections, common adverse effects, and 40% efficacy. Study participants at the methadone clinic had higher levels of consideration of treatment. These findings support the development of specific education programs regarding treatment for HCV infection for current IDUs.
尽管最近丙型肝炎病毒（HCV）感染的治疗结果有所改善，但目前很少有注射吸毒者能够获得治疗项目。我们研究了HCV感染的自然史、治疗知识，以及寻求HCV感染治疗的障碍和意愿。从悉尼市中心的一家初级卫生机构和美沙酮诊所抽取了100名自我报告HCV呈阳性的当前注射吸毒者作为便利样本，完成了一份由访谈员填写的问卷。参与者对HCV感染的自然史有一定了解，但对HCV感染治疗的知识了解较少。大多数人认为当前是注射吸毒者是治疗的排除标准。尽管如此，70%-80%的注射吸毒者表示，在澳大利亚当前的情况下，他们会考虑接受治疗：需要进行肝活检、皮下注射、常见不良反应以及40%的疗效。美沙酮诊所的研究参与者对治疗的考虑程度更高。这些发现支持为当前的注射吸毒者制定关于HCV感染治疗的特定教育项目。
