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整合染色体结构与功能。

Integrating chromosome structure with function.

作者信息

Rattner J B

机构信息

Department of Anatomy and Medical Biochemistry, University of Calgary, Alberta, Canada.

出版信息

Chromosoma. 1992 Mar;101(5-6):259-64. doi: 10.1007/BF00346003.

DOI:10.1007/BF00346003
PMID:1576878
Abstract

Historically, the metaphase chromosome and its architecture has been viewed as the ultimate representation of a non-functional inactive chromatin state. Recent studies of centromere (kinetochore) function in concert with studies of the placement and function of several classes of chromosomal proteins now call for a reevaluation of this view. In this article a model of chromosome structure with functional correlates is presented. Evidence for the existence of a functional chromosomal region, the "Surface Domain" is discussed.

摘要

从历史角度看，中期染色体及其结构一直被视为无功能的非活性染色质状态的最终表现形式。最近关于着丝粒（动粒）功能的研究，以及对几类染色体蛋白的定位和功能的研究，现在要求对这一观点进行重新评估。在本文中，我们提出了一个具有功能相关性的染色体结构模型。文中还讨论了功能性染色体区域“表面结构域”存在的证据。

相似文献

1
Integrating chromosome structure with function.整合染色体结构与功能。
Chromosoma. 1992 Mar;101(5-6):259-64. doi: 10.1007/BF00346003.
2
Chromosome behavior after laser microirradiation of a single kinetochore in mitotic PtK2 cells.有丝分裂的PtK2细胞中单个动粒经激光微照射后的染色体行为。
J Cell Biol. 1981 Mar;88(3):543-53. doi: 10.1083/jcb.88.3.543.
3
The force for poleward chromosome motion in Haemanthus cells acts along the length of the chromosome during metaphase but only at the kinetochore during anaphase.在风信子细胞中，染色体向极运动的力在中期沿染色体长度方向起作用，但在后期仅在动粒处起作用。
J Cell Biol. 1996 Mar;132(6):1093-104. doi: 10.1083/jcb.132.6.1093.
4
Fractionation and initial characterization of the kinetochore from mammalian metaphase chromosomes.哺乳动物中期染色体动粒的分级分离及初步表征
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5
Factors affecting the displacement of human chromosomes from the metaphase plate.影响人类染色体从中期板移位的因素。
Cytogenet Cell Genet. 1982;33(4):327-32. doi: 10.1159/000131779.
6
Kinetochore assembly and function through the cell cycle.动粒在细胞周期中的组装与功能。
Chromosoma. 2016 Sep;125(4):645-59. doi: 10.1007/s00412-016-0608-3. Epub 2016 Jul 4.
7
Traction force on a kinetochore at metaphase acts as a linear function of kinetochore fiber length.中期动粒上的牵引力作为动粒纤维长度的线性函数起作用。
J Cell Biol. 1982 May;93(2):374-89. doi: 10.1083/jcb.93.2.374.
8
Chromosomal control of meiotic cell division.减数分裂细胞分裂的染色体控制
Science. 1995 Dec 8;270(5242):1595-601. doi: 10.1126/science.270.5242.1595.
9
Movement and segregation of kinetochores experimentally detached from mammalian chromosomes.从哺乳动物染色体上实验性分离的动粒的运动和分离
Nature. 1988 Nov 17;336(6196):251-4. doi: 10.1038/336251a0.
10
Kinetochore structure and its role in chromosome orientation during the first meiotic division in male D. melanogaster.黑腹果蝇雄性减数第一次分裂期间动粒结构及其在染色体定向中的作用。
Cell. 1981 Sep;25(3):591-602. doi: 10.1016/0092-8674(81)90167-7.

引用本文的文献

1
Chromosome clustering in mitosis by the nuclear protein Ki-67.核蛋白 Ki-67 介导有丝分裂中的染色体聚集。
Biochem Soc Trans. 2021 Dec 17;49(6):2767-2776. doi: 10.1042/BST20210717.
2
Atomic force microscopy for imaging human metaphase chromosomes.用于对人类中期染色体进行成像的原子力显微镜
Chromosome Res. 2008;16(3):383-96. doi: 10.1007/s10577-008-1241-7.
3
The perichromosomal layer.染色体周层

本文引用的文献

1
The redistribution of a conserved nuclear envelope protein during the cell cycle suggests a pathway for chromosome condensation.一种保守的核膜蛋白在细胞周期中的重新分布提示了一种染色体浓缩的途径。
Cell. 1984 Jan;36(1):83-92. doi: 10.1016/0092-8674(84)90076-x.
2
Changes in distribution of nuclear matrix antigens during the mitotic cell cycle.有丝分裂细胞周期中核基质抗原分布的变化。
J Cell Biol. 1984 Aug;99(2):661-71. doi: 10.1083/jcb.99.2.661.
3
Localization of nucleolar phosphoproteins B23 and C23 during mitosis.有丝分裂期间核仁磷蛋白B23和C23的定位
Chromosoma. 2005 Dec;114(6):377-88. doi: 10.1007/s00412-005-0021-9. Epub 2005 Nov 15.
4
Elasticity measurements show the existence of thin rigid cores inside mitotic chromosomes.弹性测量结果表明，有丝分裂染色体内部存在薄的刚性核心。
J Cell Biol. 1999 Apr 19;145(2):215-23. doi: 10.1083/jcb.145.2.215.
5
Autoantibodies to components of the mitotic apparatus.针对有丝分裂器成分的自身抗体。
Mol Biol Rep. 1998 Jul;25(3):143-55. doi: 10.1023/a:1016523013819.
6
Molecular cloning of metaphase chromosome protein 1 (MCP1), a novel human autoantigen that associates with condensed chromosomes during mitosis.中期染色体蛋白1（MCP1）的分子克隆，MCP1是一种新型人类自身抗原，在有丝分裂期间与浓缩染色体相关联。
Chromosome Res. 1998 Feb;6(2):85-95. doi: 10.1023/a:1009230811398.
7
Relative distribution of rDNA and proteins of the RNA polymerase I transcription machinery at chromosomal NORs.核糖体DNA（rDNA）与RNA聚合酶I转录机制的蛋白质在染色体核仁组织区（NORs）的相对分布。
Chromosoma. 1997 Jun;105(7-8):459-69. doi: 10.1007/BF02510483.
8
Characterization of a cell cycle-dependent nuclear autoantigen.一种细胞周期依赖性核自身抗原的特性分析。
Mol Biol Rep. 1996;23(3-4):197-203. doi: 10.1007/BF00351169.
9
Changes in chromosomal ultrastructure during the cell cycle.细胞周期中染色体超微结构的变化。
Chromosome Res. 1996 Jun;4(4):288-94. doi: 10.1007/BF02263679.
10
The structure of human S-phase chromosome fibres.人类S期染色体纤维的结构。
Chromosome Res. 1994 Jan;2(1):47-52. doi: 10.1007/BF01539453.
Exp Cell Res. 1983 Jun;146(1):139-49. doi: 10.1016/0014-4827(83)90332-4.
4
Properties of the kinetochore in vitro. II. Microtubule capture and ATP-dependent translocation.体外动粒的特性。II. 微管捕获与ATP依赖的转运
J Cell Biol. 1985 Sep;101(3):766-77. doi: 10.1083/jcb.101.3.766.
5
Radial loops and helical coils coexist in metaphase chromosomes.径向环和螺旋线圈共存于中期染色体中。
Cell. 1985 Aug;42(1):291-6. doi: 10.1016/s0092-8674(85)80124-0.
6
Localization of ribosomal protein S1 in the granular component of the interphase nucleolus and its distribution during mitosis.核糖体蛋白S1在间期核仁颗粒组分中的定位及其在有丝分裂期间的分布。
J Cell Biol. 1985 Mar;100(3):873-86. doi: 10.1083/jcb.100.3.873.
7
Nuclear lamins and peripheral nuclear antigens during fertilization and embryogenesis in mice and sea urchins.小鼠和海胆受精及胚胎发生过程中的核纤层蛋白和核周边抗原。
Proc Natl Acad Sci U S A. 1985 Jul;82(14):4727-31. doi: 10.1073/pnas.82.14.4727.
8
Chromosomes move poleward in anaphase along stationary microtubules that coordinately disassemble from their kinetochore ends.在后期，染色体沿着固定的微管向两极移动，这些微管从其动粒末端协同解聚。
J Cell Biol. 1987 Jan;104(1):9-18. doi: 10.1083/jcb.104.1.9.
9
A monoclonal antibody against the nucleus reveals the presence of a common protein in the nuclear envelope, the perichromosomal region, and cytoplasmic vesicles.一种针对细胞核的单克隆抗体显示，在核膜、染色体周围区域和细胞质小泡中存在一种共同蛋白。
J Cell Biol. 1987 Jan;104(1):1-7. doi: 10.1083/jcb.104.1.1.
10
Involvement of a nucleolar component, perichromonucleolin, in the condensation and decondensation of chromosomes.
Proc Natl Acad Sci U S A. 1987 Nov;84(22):7953-6. doi: 10.1073/pnas.84.22.7953.