Laboratory for Structural and Computational Proteomics, Carlos Chagas Institute, Fiocruz, Paraná, Curitiba, Brazil.
Clinical Hospital of the Federal University of Paraná, Paraná, Brazil.
Sci Rep. 2020 Jun 25;10(1):10335. doi: 10.1038/s41598-020-67113-3.
Meningiomas are among the most common primary tumors of the central nervous system (CNS) and originate from the arachnoid or meningothelial cells of the meninges. Surgery is the first option of treatment, but depending on the location and invasion patterns, complete removal of the tumor is not always feasible. Reports indicate many differences in meningiomas from male versus female patients; for example, incidence is higher in females, whereas males usually develop the malignant and more aggressive type. With this as motivation, we used shotgun proteomics to compare the proteomic profile of grade I meningioma biopsies of male and female patients. Our results listed several differentially abundant proteins between the two groups; some examples are S100-A4 and proteins involved in RNA splicing events. For males, we identified enriched pathways for cell-matrix organization and for females, pathways related to RNA transporting and processing. We believe our findings contribute to the understanding of the molecular differences between grade I meningiomas of female and male patients.
脑膜瘤是中枢神经系统（CNS）最常见的原发性肿瘤之一，起源于脑膜的蛛网膜或脑膜内皮细胞。手术是治疗的首选，但根据肿瘤的位置和侵袭模式，并非总能完全切除肿瘤。报告显示，男性和女性脑膜瘤患者之间存在许多差异；例如，发病率在女性中更高，而男性通常会发展为恶性且更具侵袭性的类型。有鉴于此，我们使用鸟枪法蛋白质组学比较了男性和女性一级脑膜瘤活检组织的蛋白质组图谱。我们的结果列出了两组之间存在差异的几种丰富蛋白；一些例子是 S100-A4 和参与 RNA 剪接事件的蛋白质。对于男性，我们鉴定出与细胞-基质组织相关的富集途径，而对于女性，与 RNA 转运和加工相关的途径。我们相信我们的发现有助于理解女性和男性一级脑膜瘤患者之间的分子差异。
