Chuang Ronald Y, Suzuki Shunji, Chuang Ted K, Miyagi Tomoko, Chuang Linda F, Doi Roy H
Department of Medical Pharmacology and Toxicology, School of Medicine and Section of Molecular and Cellular Biology, University of California, Davis, California 95616, USA.
Front Biosci. 2005 May 1;10:1666-77. doi: 10.2741/1651.
This review is a concise description of the study undertaken to examine the modulation by opioids of simian acquired immunodeficiency syndrome (SAIDS) induced by inoculation of rhesus monkeys with simian AIDS virus SIVmac239. The study showed that the replication rate of the virus was several times greater in monkeys made dependent on morphine than in those of non-morphine treated monkeys. Further, a significant change in the mutation rate of the infecting virus in morphine-treated monkeys resulted in the production of mutants that were silent to conventional serological screening tests as well as resistant to AZT. In addition, opioid and chemokine receptors involved were identified in immune cells and a full comparative spectrum of the compromise of the immune system was examined allowing subsequent studies to evaluate wherein the modulation of the development of the syndrome could be better characterized. The data gathered to date are unique and germane to furthering our understanding of AIDS in humans and its subsequent treatment thereof.
本综述简要描述了一项研究，该研究旨在检测阿片类药物对恒河猴接种猿猴免疫缺陷病毒SIVmac239诱导的猿猴获得性免疫缺陷综合征（SAIDS）的调节作用。研究表明，对吗啡产生依赖的猴子体内病毒的复制率比未接受吗啡治疗的猴子高出数倍。此外，在接受吗啡治疗的猴子中，感染病毒的突变率发生了显著变化，导致产生的突变体对传统血清学筛查试验呈阴性，且对齐多夫定具有抗性。此外，在免疫细胞中鉴定出了相关的阿片类药物和趋化因子受体，并对免疫系统受损的完整比较谱进行了研究，以便后续研究能够更好地确定综合征发展调节的特征所在。迄今为止收集的数据对于加深我们对人类艾滋病及其后续治疗的理解具有独特性和相关性。
