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冠状动脉疾病患者手术使用方面的种族差异对功能状态结局的影响。

Influence of racial disparities in procedure use on functional status outcomes among patients with coronary artery disease.

作者信息

Kaul Padma, Lytle Barbara L, Spertus John A, DeLong Elizabeth R, Peterson Eric D

机构信息

University of Alberta, Edmonton, Alberta, Canada.

出版信息

Circulation. 2005 Mar 15;111(10):1284-90. doi: 10.1161/01.CIR.0000157731.66268.E1.

Abstract

BACKGROUND

Although black cardiac patients receive fewer revascularization procedures than whites, it is unclear whether this has a detrimental impact on outcomes. The objective of our study was to compare 6-month functional status and angina outcomes among blacks and whites with documented coronary disease and to assess whether differential use of revascularization procedures affects these outcomes.

METHODS AND RESULTS

We identified a prospective cohort of 1534 white and 337 black patients undergoing cardiac catheterization between August 1998 and April 2001. Health status was assessed at baseline and 6 months with the Short-Form 36 (SF-36) Health Survey and the Seattle Angina Questionnaire (SAQ) Angina Frequency Scale. Compared with whites, blacks received fewer coronary revascularization procedures (52.5% versus 66.0%; P<0.01). By 6 months, blacks had similar mortality (odds ratio, 1.03; 95% CI, 0.57 to 1.9) but worse scores in 5 SF-36 domains (physical, social, role physical, role emotional, and mental health function). Blacks also reported higher rates of angina at 6 months than whites (34.2% versus 24.6%; P<0.01). After adjustment for baseline functional status and clinical and demographic variables, blacks had significantly worse summary physical component scores, summary mental component scores, and SAQ Angina Frequency Scale scores. However, differences in physical component summary scores and SAQ scores between blacks and whites were no longer significant after adjustment for revascularization status.

CONCLUSIONS

Our study is among the first to document greater symptoms and functional impairment among black cardiac patients relative to whites. Differential use of coronary revascularization may contribute to the poorer functional outcomes observed among black patients with documented coronary disease.

摘要

背景

尽管黑人心脏病患者接受的血运重建手术比白人少,但尚不清楚这是否会对治疗结果产生不利影响。我们研究的目的是比较有冠心病记录的黑人和白人患者6个月时的功能状态和心绞痛结局,并评估血运重建手术的不同使用情况是否会影响这些结局。

方法与结果

我们确定了一个前瞻性队列,其中包括1998年8月至2001年4月期间接受心脏导管插入术的1534名白人患者和337名黑人患者。在基线和6个月时,使用简明健康调查问卷(SF-36)和西雅图心绞痛问卷(SAQ)心绞痛频率量表对健康状况进行评估。与白人相比,黑人接受的冠状动脉血运重建手术较少(52.5%对66.0%;P<0.01)。到6个月时,黑人的死亡率相似(优势比,1.03;95%CI,0.57至1.9),但在SF-36的5个领域(身体、社会、角色身体、角色情感和心理健康功能)得分更差。黑人在6个月时报告的心绞痛发生率也高于白人(34.2%对24.6%;P<0.01)。在对基线功能状态、临床和人口统计学变量进行调整后,黑人的身体成分总分、精神成分总分和SAQ心绞痛频率量表得分明显更差。然而,在对血运重建状态进行调整后,黑人和白人在身体成分总分和SAQ得分上的差异不再显著。

结论

我们的研究是首批记录黑人心脏病患者相对于白人有更严重症状和功能损害的研究之一。冠状动脉血运重建手术的不同使用情况可能导致有冠心病记录的黑人患者观察到的功能结局较差。

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