Rea Rhonda S, Ansani Nicole T, Seybert Amy L
Medical Intensive Care Unit, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Ann Pharmacother. 2005 May;39(5):913-7. doi: 10.1345/aph.1E228. Epub 2005 Mar 15.
To evaluate the role of inhaled nitric oxide (iNO) in adult heart or lung transplant recipients.
Pertinent literature was identified via a MEDLINE search (1966-July 2004).
Pulmonary hypertension leading to right ventricular failure and ischemic reperfusion injury are complications following heart or lung transplant, respectively. A study of 16 heart transplant patients showed improvement in hemodynamic parameters and preservation of right ventricular function, but no improvement in mortality using iNO. Studies of lung transplant patients showed no benefit of iNO on mechanical ventilation duration, hospital length of stay, or mortality, but some studies indicate an improvement in hemodynamic parameters.
iNO shows hemodynamic benefits in early postoperative heart transplant patients with preexisting pulmonary hypertension, and variable hemodynamic benefits in lung transplant recipients. Currently, morbidity and mortality data are not favorable for either indication; use of iNO is supportive and requires further study.
评估吸入一氧化氮（iNO）在成人心脏或肺移植受者中的作用。
通过MEDLINE检索（1966年 - 2004年7月）确定相关文献。
肺动脉高压导致右心室衰竭以及缺血再灌注损伤分别是心脏或肺移植后的并发症。一项对16例心脏移植患者的研究显示，使用iNO后血流动力学参数有所改善，右心室功能得以保留，但死亡率并未改善。对肺移植患者的研究表明，iNO对机械通气时间、住院时间或死亡率并无益处，但一些研究显示血流动力学参数有所改善。
iNO对术后早期存在肺动脉高压的心脏移植患者显示出血流动力学益处，对肺移植受者的血流动力学益处则存在差异。目前，无论是哪种适应证，发病率和死亡率数据都不乐观；iNO的使用具有支持性，需要进一步研究。
