Yilmaz Deniz, Kavakli Kaan, Ozkayin Nese
Ege University, Faculty of Medicine, Department of Pediatric Hematology, Izmir, Turkey.
Pediatr Hematol Oncol. 2005 Jan-Feb;22(1):41-8. doi: 10.1080/08880010590896251.
Twenty-eight children with HSP and 79 healthy children were entered into study. Activities of protein C, free-protein S and antithrombin, activated protein C resistance, levels of fibrinogen. D-dimer, thrombin-antithrombin complex (TAT), prothrombin fragments 1 + 2 (PF(1+2)), and von Willebrand factor antigen (vWAg) and its activity (RiCof) were investigated in acute and recovery phases of HSP and controls. Fibrinogen, D-dimer, TAT, PF(1+2), vWAg, and RiCof levels in patients with HSP during the acute phase were significantly higher than those of recovery phase and of the controls. A significant correlation was detected between severity of disease and TAT, PF(1+2), vWAg, and D-dimer levels.
28名过敏性紫癜（HSP）患儿和79名健康儿童纳入研究。在HSP患儿及对照儿童的急性期和恢复期，检测了蛋白C、游离蛋白S、抗凝血酶活性、活化蛋白C抵抗、纤维蛋白原、D-二聚体、凝血酶-抗凝血酶复合物（TAT）、凝血酶原片段1+2（PF(1+2)）、血管性血友病因子抗原（vWAg）及其活性（RiCof）。HSP患儿急性期的纤维蛋白原、D-二聚体、TAT、PF(1+2)、vWAg和RiCof水平显著高于恢复期及对照组。疾病严重程度与TAT、PF(1+2)、vWAg和D-二聚体水平之间存在显著相关性。
