Arkel Y S, Paidas M J, Ku D H
Maternal &Fetal Medicine Division, Department of OB/Gyn, NYU Medical Center, New York, New York 10016, USA.
Blood Coagul Fibrinolysis. 2002 Apr;13(3):199-205. doi: 10.1097/00001721-200204000-00005.
A total of 260 consecutive patients, referred for hypercoagulable assessment, was included in this study. Four coagulation activation markers were utilized to assess these patients [enzyme-linked immunosorbent assays for soluble fibrin polymer (TpP), prothrombin fragment 1.2, thrombin-antithrombin complex, and D-dimer]. The mean levels of the activation markers directly correlated with the number of hypercoagulable abnormalities. The percentage of patients with increased TpP levels for each group was lower than the other activation markers. The findings indicate that activation markers reflect the number of underlying thrombophilic abnormalities. Our data suggest that there is a utility in performing a panel of coagulation activation markers to assess the thrombotic risk. The measurement of soluble fibrin polymer may be more reflective of an impending vascular event.
本研究纳入了总共260例因高凝状态评估而转诊的连续患者。使用四种凝血激活标志物对这些患者进行评估[可溶性纤维蛋白聚合物（TpP）、凝血酶原片段1.2、凝血酶 - 抗凝血酶复合物和D - 二聚体的酶联免疫吸附测定]。激活标志物的平均水平与高凝异常的数量直接相关。每组中TpP水平升高的患者百分比低于其他激活标志物。这些发现表明激活标志物反映了潜在的血栓形成异常的数量。我们的数据表明，进行一组凝血激活标志物检测以评估血栓形成风险是有用的。可溶性纤维蛋白聚合物的测量可能更能反映即将发生的血管事件。
