Herzum M, Maisch B
Philipps University of Marburg, Division of Internal Medicine and Cardiology, FRG.
Herz. 1992 Apr;17(2):91-6.
Myocarditis is characterized by an infiltration of poly- and mononuclear leucocytes next to necrosis of myofibers in the heart. Various viruses induce this cardiac disorder in most cases, either by their direct cytotoxic action on the cardiocytes or by humoral and cellular immune reactions to the myocardium arising after the infection. Epidemiological and experimental and serological studies suggest, that viral myocarditis may lead to dilated heart muscle disease. Therapy consists of reducing cardiac stress by physical inactivity and drugs decreasing cardiac pre- and afterload. Immunosuppression is beneficial in some but not all patients with myocarditis.
心肌炎的特征是在心肌纤维坏死旁有多形核白细胞和单核白细胞浸润。在大多数情况下，多种病毒可诱发这种心脏疾病，要么通过其对心肌细胞的直接细胞毒性作用，要么通过感染后对心肌产生的体液和细胞免疫反应。流行病学、实验和血清学研究表明，病毒性心肌炎可能导致扩张型心肌病。治疗包括通过减少体力活动和使用降低心脏前负荷和后负荷的药物来减轻心脏压力。免疫抑制对部分但并非所有心肌炎患者有益。
