慢性乙醇处理对成年大鼠视神经中胶质纤维酸性蛋白表达的影响：一项免疫细胞化学研究。
Effects of chronic ethanol treatment on glial fibrillary acidic protein expression in adult rat optic nerve: an immunocytochemical study.
作者信息
Gonca Süheyla, Filiz Serdar, Dalçik Cannur, Yardimoğlu Melda, Dalçik Hakki, Yazir Yusufhan, Erden B Faruk
机构信息
Department of Histology and Embryology, Faculty of Medicine, Kocaeli University, 41900 Derince, Izmit-Kocaeli, Turkey.
出版信息
Cell Biol Int. 2005 Feb;29(2):169-72. doi: 10.1016/j.cellbi.2004.11.020. Epub 2005 Jan 22.
Glial fibrillary acidic protein (GFAP) is used as a marker of astrocyte response to various central nervous system injuries. In the present study, the effects of chronic ethanol administration on GFAP immunoreactivity were evaluated in astrocytes of the adult optic nerve head. The results demonstrated that ethanol exposure significantly and dramatically increases GFAP immunoreactivity and the number of immunoreactive astrocytes (p<0.001). In addition, GFAP immunoreactive cells in the optic nerve showed extensive hypertrophy (p<0.001).
胶质纤维酸性蛋白（GFAP）被用作星形胶质细胞对各种中枢神经系统损伤反应的标志物。在本研究中，评估了成年视神经乳头星形胶质细胞中慢性乙醇给药对GFAP免疫反应性的影响。结果表明，乙醇暴露显著且大幅增加了GFAP免疫反应性和免疫反应性星形胶质细胞的数量（p<0.001）。此外，视神经中的GFAP免疫反应性细胞显示出广泛的肥大（p<0.001）。
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