鼠伤寒沙门氏菌肠毒素介导的液体分泌。

Salmonella typhimurium enterotoxin mediated fluid secretion.

作者信息

Khurana S, Ganguly N K, Panigrahi D, Khullar M, Walia B N

机构信息

Department of Experimental Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh.

出版信息

Indian J Med Res. 1992 Jan;95:17-20.

PMID:1577513

Abstract

Unidirectional Na+ and Cl- fluxes were studied in rats treated with S. typhimurium enterotoxin (S-LT). There was net absorption of Na+ and Cl- in the control group, while in the toxin treated animals there was net secretion of Na+ and Cl- (P less than 0.001). There was no change in the transport of D-glucose in the toxin treated group as compared to the control animals. The Na+, K(+)-ATPase pump was unaltered in the S-LT treated animals (198.67 +/- 11.23 nmoles Pi/mg protein/min) as compared to the control group (189.93 +/- 10.09 nmoles Pi/mg protein/min). There was no change in the unidirectional fluxes of Ca+2 in the S-LT treated animals as compared to the control animals, suggesting no change in the permeability of the S-LT treated intestinal membrane to Ca+2.

摘要

对用鼠伤寒沙门氏菌肠毒素（S-LT）处理的大鼠的单向钠和氯通量进行了研究。对照组存在钠和氯的净吸收，而在毒素处理的动物中存在钠和氯的净分泌（P<0.001）。与对照动物相比，毒素处理组中D-葡萄糖的转运没有变化。与对照组（189.93±10.09纳摩尔无机磷/毫克蛋白质/分钟）相比，S-LT处理的动物中钠钾ATP酶泵未改变（198.67±11.23纳摩尔无机磷/毫克蛋白质/分钟）。与对照动物相比，S-LT处理的动物中钙离子的单向通量没有变化，表明S-LT处理的肠膜对钙离子的通透性没有变化。