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经典型克罗恩病的外科治疗与策略

Surgical management and strategy in classical Crohn's disease.

作者信息

Hultén L

机构信息

Surgical Department II, University of Göteborg, Sweden.

出版信息

Int Surg. 1992 Jan-Mar;77(1):2-8.

PMID:1577576
Abstract

Surgical treatment for Crohn's disease of the small bowel or ileocecal region consists of resection. Surgery is not for cure but rather to relieve symptoms. In this respect resectional surgery has proved to be superior to present day medical management. The main arguments against resectional surgery are that it causes a fair amount of operative morbidity and mortality. However, these hazards can be reduced by recommending surgery at an earlier stage of the disease before the onset of complications. Furthermore it should be followed by a high incidence of recurrence of the disease, amounting to about 50% by 10 years. However, recurrences can be excised with no increased likelihood of further recurrence, and by a combination of resection and reresection as required, most patients can be afforded prolonged periods of symptomatic relief; limited resections are recommended with removal of macroscopically diseased bowel. And last that intestinal absorption is grossly impaired, especially after major or repeated resections of the small bowel. However, ileal resection causes a characteristic malabsorption pattern, qualitatively and quantitatively related to the extent of resection. The consequences such as diarrhea and possible hematological and nutritional disturbances and a predisposition to the formation of biliary and urinary calculi can be successfully prevented and/or managed by medical support and dietary restrictions. Even a loss of up to 50% of the entire small intestine is often compatible with a reasonably good state of general health, particularly if most of the colon has been preserved. Fortunately, such extensive intestinal losses are rare, even after 2 or 3 resections.

摘要

小肠或回盲部克罗恩病的外科治疗包括切除手术。手术并非为了治愈疾病,而是为了缓解症状。在这方面,切除手术已被证明优于当今的药物治疗。反对切除手术的主要理由是它会导致相当数量的手术并发症和死亡率。然而,通过在疾病早期并发症出现之前推荐手术,可以降低这些风险。此外,该病复发率较高,到10年时约为50%。然而,复发病变可以切除,且不会增加进一步复发的可能性,通过根据需要进行切除和再次切除相结合,大多数患者可以获得较长时间的症状缓解;建议进行有限切除,切除肉眼可见病变的肠段。最后,肠道吸收会严重受损,尤其是在小肠进行大手术或多次手术后。然而,回肠切除会导致一种典型的吸收不良模式,在质量和数量上与切除范围相关。腹泻以及可能的血液学和营养紊乱以及形成胆石和尿路结石的倾向等后果,可以通过医学支持和饮食限制成功预防和/或处理。即使整个小肠损失高达50%,通常也能维持相当良好的总体健康状态,特别是如果大部分结肠得以保留。幸运的是,即使经过2或3次切除,如此广泛的肠道损失也很少见。

相似文献

1
Surgical management and strategy in classical Crohn's disease.经典型克罗恩病的外科治疗与策略
Int Surg. 1992 Jan-Mar;77(1):2-8.
2
Long-term outcome after ileocecal resection for Crohn's disease.克罗恩病回盲部切除术后的长期预后
Am Surg. 1997 Jul;63(7):627-33.
3
[Recurrence of Crohn's disease after surgery--causes and risks].[克罗恩病术后复发——原因与风险]
Zentralbl Chir. 2008 Apr;133(2):182-7. doi: 10.1055/s-2008-1004743.
4
[Crohn disease: prognostic factors and therapeutic choices].[克罗恩病:预后因素与治疗选择]
Chir Ital. 2002 Mar-Apr;54(2):141-54.
5
Long-term follow-up after resectional surgery in patients with Crohn's disease involving the colon.克罗恩病累及结肠患者行切除术后的长期随访
Z Gastroenterol. 1998 Aug;36(8):619-24.
6
The role of strictureplasty in Crohn's disease.狭窄成形术在克罗恩病中的作用。
Int Surg. 1992 Jan-Mar;77(1):15-8.
7
Management of the short bowel syndrome after extensive small bowel resection.广泛小肠切除术后短肠综合征的管理
Best Pract Res Clin Gastroenterol. 2004 Oct;18(5):977-92. doi: 10.1016/j.bpg.2004.05.002.
8
[Surgical concepts in Crohn disease of the terminal ileum and colon].[回肠末端和结肠克罗恩病的外科治疗理念]
Zentralbl Chir. 1998;123(4):331-7.
9
Patterns and operative treatment of recurrent Crohn's disease: a prospective longitudinal study.复发性克罗恩病的模式及手术治疗:一项前瞻性纵向研究
Surgery. 2006 Oct;140(4):649-54. doi: 10.1016/j.surg.2006.07.011. Epub 2006 Sep 7.
10
[Factors affecting recurrence after surgical treatment of Crohn disease].[克罗恩病手术治疗后影响复发的因素]
Minerva Gastroenterol Dietol. 1995 Jun;41(2):135-42.

引用本文的文献

1
Impact of ileocecal resection and concomitant antibiotics on the microbiome of the murine jejunum and colon.回盲部切除和联合使用抗生素对小鼠空肠和结肠微生物组的影响。
PLoS One. 2013 Aug 27;8(8):e73140. doi: 10.1371/journal.pone.0073140. eCollection 2013.
2
Postoperative outcome of Crohn's disease in 30 children.30例儿童克罗恩病的术后结果
Gut. 1998 Nov;43(5):634-8. doi: 10.1136/gut.43.5.634.
3
Timing of ileocolonic resection for symptomatic Crohn's disease--the patient's view.有症状克罗恩病的回结肠切除术时机——患者视角
Gut. 1994 May;35(5):656-7. doi: 10.1136/gut.35.5.656.