Begum Mosammat Rashida, Begum Anowara, Quadir Ehsan, Akhter Sayeba, Shamsuddin Latifa
OB/GYN Dhaka Medical College and Hospital, Bangladesh.
MedGenMed. 2004 Oct 8;6(4):52.
This descriptive study, conducted at Dhaka Medical College and Hospital, Bangladesh, includes 2956 consecutive eclamptic patients who were admitted between 1998 and 2000 and evaluates their outcomes after treatment with magnesium sulfate. Although magnesium sulfate controls convulsion efficiently, death from eclampsia remains high in our country. Thus, a second purpose of this study was to identify additional factors responsible for death from eclampsia. Among 32,999 obstetric patients admitted to the hospital during the years 1998 to 2000, 2956 were eclamptic, yielding an incidence of 9%. The antepartum/intrapartum and postpartum incidences of eclampsia were 80% and 20%, respectively. Among the patients with eclampsia, 79% had good prognosis without any added complication except convulsion, and 21% had other complications. For the period 1998 to 2000, the rate of maternal death from eclampsia was 8.6%, which was lower than that of the immediate past year (1997) for which the mortality was 16%. Changing the protocol from diazepam to magnesium sulfate for control of convulsion significantly reduced the incidence of death. But reduction of the risk of death was difficult when patients had developed complications. Most of the patients in the group who had complications died (98%); these complications developed as a result of a delayed decision for treatment. Therefore, efforts should be directed at developing awareness to receive treatment at an appropriate time to prevent the development of eclampsia and to reduce the mortality from eclampsia and its complications.
这项描述性研究在孟加拉国达卡医学院及医院开展,纳入了1998年至2000年间连续收治的2956例子痫患者,并评估了她们接受硫酸镁治疗后的结局。尽管硫酸镁能有效控制惊厥,但我国子痫导致的死亡发生率仍然很高。因此,本研究的第二个目的是确定导致子痫死亡的其他因素。在1998年至2000年间入院的32999例产科患者中,2956例为子痫患者,发病率为9%。子痫的产前/产时和产后发病率分别为80%和20%。子痫患者中,79%预后良好,除惊厥外无其他并发症,21%有其他并发症。1998年至2000年期间,子痫导致的孕产妇死亡率为8.6%,低于上一年(1997年),后者的死亡率为16%。将控制惊厥的方案从地西泮改为硫酸镁显著降低了死亡率。但当患者出现并发症时,降低死亡风险则很困难。出现并发症的患者组中的大多数患者死亡(98%);这些并发症是由于治疗决策延迟所致。因此,应致力于提高人们在适当时间接受治疗的意识,以预防子痫的发生,并降低子痫及其并发症导致的死亡率。