Tai Jennifer H, Williams John V, Edwards Kathryn M, Wright Peter F, Crowe James E, Dermody Terence S
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2581, USA.
J Infect Dis. 2005 Apr 15;191(8):1221-4. doi: 10.1086/428911. Epub 2005 Mar 8.
Although reovirus infections are thought to be common in adults, there have been few assessments of the seroprevalence of reovirus in young children. We developed an indirect enzyme-linked immunosorbent assay to measure levels of total antireovirus immunoglobulin A, G, and M in serum specimens collected from otherwise healthy infants and children (1 month to 5 years of age) in Nashville, Tennessee. Of the 272 serum specimens evaluated, 64 (23.5%) tested positive for reovirus-specific antibodies. We observed an age-dependent increase in reovirus-specific antibodies in children 1 year of age and older, peaking at 50.0% in children 5-6 years of age. These findings suggest that reovirus infections are common during early childhood.
尽管人们认为呼肠孤病毒感染在成年人中很常见，但针对幼儿呼肠孤病毒血清阳性率的评估却很少。我们开发了一种间接酶联免疫吸附测定法，以测量从田纳西州纳什维尔市健康的婴儿和儿童（1个月至5岁）采集的血清样本中抗呼肠孤病毒免疫球蛋白A、G和M的总量。在评估的272份血清样本中，64份（23.5%）呼肠孤病毒特异性抗体检测呈阳性。我们观察到1岁及以上儿童中呼肠孤病毒特异性抗体随年龄增长而增加，在5至6岁儿童中达到峰值50.0%。这些发现表明，呼肠孤病毒感染在幼儿期很常见。
