一名慢性皮肤性红斑狼疮患者在接受喹吖因治疗时发生横纹肌溶解症。

Rhabdomyolysis associated with quinacrine therapy in a patient with chronic cutaneous lupus erythematosus.

作者信息

Creel Naomi, Werth Victoria

机构信息

Department of Dermatology, Walter Reed Army Medical Center, Washington, DC, USA.

出版信息

J Drugs Dermatol. 2005 Mar-Apr;4(2):225-7.

PMID:15776783

Abstract

We describe a patient who developed rhabdomyolysis 6 weeks after starting combination therapy with hydroxychloroquine and quinacrine for the treatment of chronic cutaneous lupus erythematosus (CCLE). Myopathy due to 4-aminoquinolone antimalarials has been well documented. It is plausible that quinacrine may induce muscle injury in a manner similar to other antimalarials but, to our knowledge, rhabdomyolysis associated with antimalarial therapy has not been reported.

摘要

我们描述了一名患者，该患者在开始使用羟氯喹和奎纳克林联合治疗慢性皮肤型红斑狼疮（CCLE）6周后发生了横纹肌溶解。4-氨基喹啉类抗疟药所致的肌病已有充分记录。奎纳克林可能以与其他抗疟药类似的方式诱导肌肉损伤，这似乎是合理的，但据我们所知，与抗疟治疗相关的横纹肌溶解尚未见报道。