Leon-Villapalos J, Wolfe K, Kangesu L
Department of Plastic and Reconstructive Surgery, St Andrews Centre for Plastic Surgery and Burns, Court Road, Broomfield, Chelmsford CM1 7ET, UK.
Br J Plast Surg. 2005 Apr;58(3):348-52. doi: 10.1016/j.bjps.2004.05.029.
The differential diagnosis between juvenile haemangiomas, vascular malformations, pyogenic granulomas and normally proliferative endothelium (granulation tissue) on the basis of histology alone is sometimes difficult. This is important because haemangiomas, are self-limiting and vascular malformations are not. We report our experience of using the immunohistochemical marker GLUT-1 to distinguish haemangiomas from vascular malformations following the initial report by North and Colleagues (1998). We studied a total of 50 specimens from patients with vascular anomalies, and found that GLUT-1 reactivity was positive in 18 out of 19 juvenile haemangiomas, negative in two out of two noninvoluting congenital haemangiomas (NICH) and negative in 29 out of 29 vascular malformations, that included capillary malformations, lymphatic malformations, venous malformations and arteriovenous malformations (95% sensitivity, 100% specificity). Pyogenic granulomas (n = 4) and granulation tissue samples (n = 4) were used as negative controls. Placenta tissue was used as positive control. GLUT-1 accurately distinguishes haemangiomas from vascular malformations, and as a result from this work, we use this technique in routine histopathological differentiation of vascular anomalies.
仅基于组织学对幼年血管瘤、血管畸形、化脓性肉芽肿和正常增殖内皮（肉芽组织）进行鉴别诊断有时很困难。这一点很重要，因为血管瘤是自限性的，而血管畸形不是。继North及其同事（1998年）首次报道后，我们报告了使用免疫组化标志物GLUT-1区分血管瘤和血管畸形的经验。我们共研究了50例血管异常患者的标本，发现19例幼年血管瘤中有18例GLUT-1反应呈阳性，2例非消退性先天性血管瘤（NICH）中有2例呈阴性，29例血管畸形（包括毛细血管畸形、淋巴管畸形、静脉畸形和动静脉畸形）中有29例呈阴性（敏感性95%，特异性100%）。4例化脓性肉芽肿和4例肉芽组织样本用作阴性对照。胎盘组织用作阳性对照。GLUT-1能准确区分血管瘤和血管畸形，基于此项研究结果，我们将该技术用于血管异常的常规组织病理学鉴别诊断。
