Passie Torsten, Hartmann Uwe, Schneider Udo, Emrich Hinderk M, Krüger Tillmann H C
Department of Clinical Psychiatry and Psychotherapy, Medical School Hannover, Carl-Neuberg-Str. 1, D-30625 Hanover, Germany.
Med Hypotheses. 2005;64(5):899-903. doi: 10.1016/j.mehy.2004.11.044.
Methylenedioxymethamphetamine (MDMA or "Ecstasy") is a major stimulant drug of abuse worldwide. MDMA produces euphoria, enhances interpersonal communication and feelings of closeness with others. In contrast to the induced emotions of affection and sensual enhancement, clinical studies show that it impairs sexual drive and functioning. In drug-free humans, sexual stimulation with orgasm induces a pronounced secretion of prolactin, which may mediate the post-orgasmic state. The phenomenological features of the psychological state induced by MDMA show some similarities with features of the post-orgasmic state. In addition, MDMA also induces a prominent increase of prolactin plasma levels with a similar time kinetic compared to the post-orgasmic prolactin increase. Here, we present the hypothesis that the impairment of sexual parameters after MDMA may be mediated by increased prolactin.
亚甲基二氧甲基苯丙胺（摇头丸或“迷幻药”）是全球主要的滥用兴奋剂药物。摇头丸能产生欣快感，增强人际交流以及与他人的亲密感。与诱导出的情感亲昵和感官增强相反，临床研究表明它会损害性欲和性功能。在未服用药物的人群中，性刺激达到性高潮会促使催乳素大量分泌，这可能介导了性高潮后的状态。摇头丸所诱导的心理状态的现象学特征与性高潮后状态的特征存在一些相似之处。此外，与性高潮后催乳素升高类似，摇头丸也会使血浆催乳素水平显著升高，且具有相似的时间动态变化。在此，我们提出一个假说，即摇头丸后性参数的损害可能是由催乳素增加介导的。
