Negri Eva, Colombo Carla, Giordano Laura, Groth Nicola, Apolone Giovanni, La Vecchia Carlo
Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy.
Vaccine. 2005 Apr 22;23(22):2851-61. doi: 10.1016/j.vaccine.2004.11.053.
We conducted a meta-analysis of 13 randomised clinical trials evaluating the efficacy of influenza vaccine in healthy children. Against culture-confirmed influenza the overall efficacy was 74% (95% confidence interval, CI, 57%-84%), 65% for inactivated and 80% for live-attenuated vaccine. Corresponding figures were 59% (95% CI 43%-71%), 63% and 54% for serologically-confirmed influenza, and 33% (95% CI 29%-36%), 33% and 34% for clinical illness. Influenza vaccine is effective in preventing laboratory-confirmed and clinical influenza in healthy children, with no clear difference between inactivated and live-attenuated vaccine. Data on infants and younger children were too scanty to allow separate assessment.
我们对13项评估流感疫苗对健康儿童疗效的随机临床试验进行了荟萃分析。对于经培养确诊的流感，总体疗效为74%（95%置信区间，CI，57%-84%），灭活疫苗为65%，减毒活疫苗为80%。对于血清学确诊的流感，相应数字分别为59%（95%CI 43%-71%）、63%和54%，对于临床疾病则为33%（95%CI 29%-36%）、33%和34%。流感疫苗可有效预防健康儿童的实验室确诊流感和临床流感，灭活疫苗和减毒活疫苗之间无明显差异。关于婴儿和年幼儿童的数据太少，无法进行单独评估。
