Peselow E D, Fieve R R, DiFiglia C
New York University School of Medicine, NY.
J Affect Disord. 1992 Apr;24(4):209-16. doi: 10.1016/0165-0327(92)90105-f.
We attempted to prospectively examine the effects of personality traits in 68 acutely depressed patients treated with desipramine over 4-5 weeks to assess whether the presence or absence of these traits played a role in response to antidepressant treatment. Overall the 39 responders had statistically significantly lower cluster III personality trait scores than non-responders, and a trend toward lower cluster I and cluster II scores. We then followed the 39 desipramine responders for up to 6 months on the dose to which they responded in accordance with standard clinical practice. Overall 23 of the 39 sustained their initial improvement, with eight relapsing and eight dropping out between 5 weeks and 6 months. When comparing these three groups with the 29 initial non-responders, those who sustained the 6-month response had statistically significantly lower cluster II, cluster III, and total personality scores than initial responders who relapsed, initial responders who dropped out and did not complete 6 months of treatment, and initial non-responders.
我们试图对68例接受去甲丙咪嗪治疗4 - 5周的急性抑郁症患者的人格特质影响进行前瞻性研究，以评估这些特质的有无是否在抗抑郁治疗反应中起作用。总体而言，39例有反应者的Ⅲ类人格特质得分在统计学上显著低于无反应者，且Ⅰ类和Ⅱ类得分有降低趋势。然后，按照标准临床实践，我们对39例去甲丙咪嗪有反应者在其有反应的剂量下随访长达6个月。总体而言，39例中有23例维持了最初的改善，8例复发，8例在5周和6个月之间退出。将这三组与29例最初无反应者进行比较时，那些维持6个月反应者的Ⅱ类、Ⅲ类人格特质得分及总体人格得分在统计学上显著低于复发的最初有反应者、退出且未完成6个月治疗的最初有反应者以及最初无反应者。
