用于诊断人类非洲锥虫病的蛋白质组指纹图谱分析

Proteomic fingerprinting for the diagnosis of human African trypanosomiasis.

作者信息

Agranoff Dan, Stich August, Abel Paulo, Krishna Sanjeev

机构信息

Department of Cellular and Molecular Medicine (Infectious Diseases), St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK.

出版信息

Trends Parasitol. 2005 Apr;21(4):154-7. doi: 10.1016/j.pt.2005.02.003.

DOI:10.1016/j.pt.2005.02.003

PMID:15780834

Abstract

Papadopoulos et al. recently reported the discovery of a diagnostic serum proteomic signature for human African trypanosomiasis (HAT), using a combination of surface-enhanced laser desorption-ionization time-of-flight (SELDI-TOF) mass spectrometry and data-mining algorithms. This novel approach, coupled with biochemical characterization of the proteins that contribute to the signature, provides powerful new tools for the development of improved diagnostic tests, disease staging and identification of potential novel drug targets in HAT.

摘要

帕帕佐普洛斯等人最近报告称，他们结合表面增强激光解吸电离飞行时间（SELDI-TOF）质谱法和数据挖掘算法，发现了一种用于人类非洲锥虫病（HAT）的诊断血清蛋白质组学特征。这种新方法，再加上对构成该特征的蛋白质进行生化特性分析，为开发改进的诊断测试、疾病分期以及鉴定HAT潜在的新型药物靶点提供了强大的新工具。