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Genome-wide association studies: a new window into immune-mediated diseases.全基因组关联研究:洞察免疫介导疾病的新窗口。
Nat Rev Immunol. 2008 Aug;8(8):631-43. doi: 10.1038/nri2361.
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Paediatric tuberculosis.小儿结核病
Lancet Infect Dis. 2008 Aug;8(8):498-510. doi: 10.1016/S1473-3099(08)70182-8.
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A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus.一种用于血液基因组学研究的模块化分析框架:在系统性红斑狼疮中的应用。
Immunity. 2008 Jul 18;29(1):150-64. doi: 10.1016/j.immuni.2008.05.012.
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Rapid diagnosis of bacterial meningitis using a microarray.使用微阵列技术快速诊断细菌性脑膜炎。
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Enabling personalized cancer medicine through analysis of gene-expression patterns.通过分析基因表达模式实现个性化癌症医学。
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Primer: genomic and proteomic tools for the molecular dissection of disease.引物:用于疾病分子剖析的基因组学和蛋白质组学工具。
Nat Clin Pract Rheumatol. 2007 Oct;3(10):580-9. doi: 10.1038/ncprheum0595.
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Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade.血液白细胞微阵列用于诊断全身型幼年特发性关节炎并监测对白细胞介素-1阻断治疗的反应。
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8
Biomarker discovery in infectious diseases using SELDI.使用表面增强激光解吸电离技术进行传染病生物标志物的发现
Future Microbiol. 2007 Feb;2(1):35-49. doi: 10.2217/17460913.2.1.35.
9
Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS.亲环素A基因(PPIA)中的调控多态性会加速艾滋病的进展。
PLoS Pathog. 2007 Jun;3(6):e88. doi: 10.1371/journal.ppat.0030088.
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The use of gene-expression profiling to identify candidate genes in human sepsis.利用基因表达谱分析来鉴定人类脓毒症中的候选基因。
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宿主生物标志物与儿科感染性疾病:从分子谱到临床应用。

Host biomarkers and paediatric infectious diseases: from molecular profiles to clinical application.

机构信息

Department of Pediatrics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

出版信息

Adv Exp Med Biol. 2010;659:19-31. doi: 10.1007/978-1-4419-0981-7_2.

DOI:10.1007/978-1-4419-0981-7_2
PMID:20204752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7122846/
Abstract

Infectious diseases are an important cause of death among children under the age of 5 (Stein et al., 2004). Most of these deaths are caused by preventable or curable infections. Limited access to medical care, antibiotics, and vaccinations remains a major problem in developing countries. But infectious diseases also continue to be an important public health issue in developed countries. With the help of modern technologies, some infections have been effectively controlled; however, new diseases such as SARS and West Nile virus infections are constantly emerging. In addition, other diseases such as malaria, tuberculosis, and bacterial pneumonia are increasingly resistant to antimicrobial treatment.

摘要

传染病是导致 5 岁以下儿童死亡的一个重要原因(Stein 等人,2004 年)。这些死亡大多是由可预防或可治愈的感染引起的。在发展中国家,获得医疗保健、抗生素和疫苗的机会有限仍然是一个主要问题。但是,传染病在发达国家仍然是一个重要的公共卫生问题。在现代技术的帮助下,一些传染病已经得到了有效控制;然而,非典和西尼罗河病毒感染等新疾病不断出现。此外,疟疾、结核病和细菌性肺炎等其他疾病对抗菌治疗的耐药性也在不断增加。