Logeart-Avramoglou D, Anagnostou F, Bizios R, Petite H
Laboratoire de Recherches Orthopédiques, Faculté de Médecine Lariboisière Saint-Louis, Université Denis Diderot, Paris, France.
J Cell Mol Med. 2005 Jan-Mar;9(1):72-84. doi: 10.1111/j.1582-4934.2005.tb00338.x.
Repair of large bone defects is still a challenge for the orthopaedic, reconstructive and maxillo-facial surgeon. Availability of pluripotent stem cells from either autologous or allogenic sources and the potential of inducing the osteogenic phenotype is motivating exploration and development of custom-tailored materials known as "bioengineered bone constructs". In such cases, the clinical scenario involves either expansion of stem cells in monolayer and loading them into a porous scaffold prior to surgery or direct cell expansion within the scaffold, and implanting this novel construct back into the donor patient. In this review, we delineate, from an engineering perspective, the progress that has been made to date and the challenges remaining in successfully translating this promising (but not yet definitively established) approach from bench to the bed site.
对于骨科、重建外科和颌面外科医生而言，修复大的骨缺损仍然是一项挑战。来自自体或异体来源的多能干细胞的可用性以及诱导成骨表型的潜力，促使人们探索和开发被称为“生物工程骨构建体”的定制材料。在这种情况下，临床方案包括在手术前将干细胞在单层中扩增并加载到多孔支架中，或者在支架内直接进行细胞扩增，然后将这种新型构建体植入供体患者体内。在这篇综述中，我们从工程学角度描述了迄今为止所取得的进展以及在将这种有前景（但尚未最终确立）的方法从实验室成功转化到临床应用中所面临的挑战。
